2. Gene
  3. Sh2b2 - SH2B adaptor protein 2 Gene

Sh2b2 - SH2B adaptor protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Aps

Gene ID: 114203 | Gene type: protein coding

About Sh2b2

Summary

Enables identical protein binding activity. Involved in nervous system development and regulation of Ras protein signal transduction. Predicted to be located in actin cytoskeleton; cytosol; and ruffle. Predicted to be active in plasma membrane. Orthologous to human SH2B2 (SH2B adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Sh2b2 Products(1)

mRNA Protein Name
NM_053669.2 NP_446121.1 SH2B adapter protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16824542 RGD
Biological Process GO Annotation Evidence Reference Source
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
9856458 RGD
involved in regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
9856458 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2B adapter protein 2

SH2 and PH domain-containing adapter protein APS

adapter protein with pleckstrin homology and Src homology 2 domains

adaptor protein with pleckstrin homology and src homology 2 domains

Sh2b2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sh2b2 Q9Z200 INSR Homo sapiens P06213
Anti Tag CoIP
16824542
Intra
Sh2b2 Q9Z200 Sh2b2 Rattus norvegicus Q9Z200
Anti Tag CoIP
16824542
Intra
Sh2b2 Q9Z200 Jak2 Mus musculus Q62120
Pull Down
16914724
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12819 SH2B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh2b2 NCBI NCBI:10603