Zmynd10 - zinc finger, MYND domain containing 10 Gene

Also Known as Blu

Species: Mus musculus

Gene Type: protein coding

Gene ID: 114602

Summary

Enables molecular adaptor activity and protein folding chaperone. Involved in outer dynein arm assembly and positive regulation of motile cilium assembly. Acts upstream of or within several processes, including cilium assembly; cilium movement; and protein localization to cilium. Located in apical plasma membrane and cytoplasm. Is expressed in bronchiole epithelium; lung; lung epithelium; nasal cavity epithelium; and nasal cavity respiratory epithelium. Used to study primary ciliary dyskinesia 22. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 22. Orthologous to human ZMYND10 (zinc finger MYND-type containing 10). [provided by Alliance of Genome Resources, Apr 2022]

Zmynd10 Products (4)

mRNA	Protein	Name
NM_001379079.1	NP_001366008.1	zinc finger MYND domain-containing protein 10 isoform 3
NM_001379080.1	NP_001366009.1	zinc finger MYND domain-containing protein 10 isoform 3
NM_001404947.1	NP_001391876.1	zinc finger MYND domain-containing protein 10 isoform 5
NM_053253.4	NP_444483.2	zinc finger MYND domain-containing protein 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	29916806	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	29916806	MGI
enables protein folding chaperone	IMP IMP: Inferred from mutant phenotype	29916806	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cilium movement	IMP IMP: Inferred from mutant phenotype	29916806	MGI
acts upstream of or within inner dynein arm assembly	IMP IMP: Inferred from mutant phenotype	29916806	MGI
involved in inner dynein arm assembly	IMP IMP: Inferred from mutant phenotype	29601588	MGI
acts upstream of or within motile cilium assembly	IMP IMP: Inferred from mutant phenotype	29916806	MGI
acts upstream of or within outer dynein arm assembly	IMP IMP: Inferred from mutant phenotype	29916806	MGI
involved in outer dynein arm assembly	IMP IMP: Inferred from mutant phenotype	29601588	MGI
involved in positive regulation of motile cilium assembly	IMP IMP: Inferred from mutant phenotype	29601588	MGI
acts upstream of or within protein folding	IMP IMP: Inferred from mutant phenotype	29916806	MGI
acts upstream of or within protein localization to cilium	IMP IMP: Inferred from mutant phenotype	29916806	MGI
acts upstream of or within sperm motility	IMP IMP: Inferred from mutant phenotype	29916806	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	29601588	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	29916806	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger MYND domain-containing protein 10	protein BLu

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16093	ZMYND10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zmynd10	NCBI	NCBI:51364