Slc5a5 - solute carrier family 5 member 5 Gene

Also Known as Nis

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114613

Summary

Enables sodium:iodide symporter activity. Involved in iodide transmembrane transport and sodium ion transport. Is active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a5 Products (1)

mRNA Protein Name
NM_052983.2 NP_443215.2 sodium/iodide cotransporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables iodide transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
18339708 RGD
enables sodium:iodide symporter activity IDA
IDA: Inferred from direct assay
8559252 RGD
Biological Process GO Annotation Evidence References Source
involved in iodide transmembrane transport IMP
IMP: Inferred from mutant phenotype
18339708 RGD
involved in iodide transport IDA
IDA: Inferred from direct assay
8559252 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
8559252 RGD
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
18339708 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9341168 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/iodide cotransporter

  • Na(+)/I(-) cotransporter

  • Na(+)/I(-) symporter

  • Na+/I- symporter

  • sodium/iodide symporter

  • solute carrier family 5 (sodium iodide symporter), member 5

  • solute carrier family 5 (sodium/iodide cotransporter), member 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13291 SLC5A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc5a5 NCBI NCBI:6528