2. Gene
  3. Actc1 - actin, alpha, cardiac muscle 1 Gene

Actc1 - actin, alpha, cardiac muscle 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Actc-1

Gene ID: 11464 | Gene type: protein coding

About Actc1

Summary

Predicted to enable ATP binding activity; microfilament motor activity; and Myosin binding activity. Acts upstream of or within several processes, including actin-mediated cell contraction; cardiac muscle tissue morphogenesis; and myofibril assembly. Located in I band. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Used to study dilated cardiomyopathy 1R. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1). [provided by Alliance of Genome Resources, Apr 2022]

Actc1 Products(1)

mRNA Protein Name
NM_009608.4 NP_033738.1 actin, alpha cardiac muscle 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22982234 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin-mediated cell contraction IMP
IMP: Inferred from mutant phenotype
22750946 MGI
acts upstream of or within actomyosin structure organization IMP
IMP: Inferred from mutant phenotype
14605248 MGI
acts upstream of or within cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
14605248 MGI
acts upstream of or within cardiac myofibril assembly IMP
IMP: Inferred from mutant phenotype
9114002 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
14605248 MGI
acts upstream of or within skeletal muscle thin filament assembly IMP
IMP: Inferred from mutant phenotype
9114002 MGI
Cellular Component GO Annotation Evidence Reference Source
located in I band IDA
IDA: Inferred from direct assay
16481394 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24413018 MGI
is active in synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24413018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin, alpha cardiac muscle 1

actin alpha cardiac

alpha-cardiac actin

alphac-actin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00217 ACTC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actc1 NCBI NCBI:70