Rad51c - RAD51 paralog C Gene

Also Known as R51H3; Rad51l2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 114714

Summary

Enables crossover junction endodeoxyribonuclease activity. Involved in telomere maintenance via recombination. Acts upstream of or within meiotic nuclear division and spermatogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian Cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Apr 2022]

Rad51c Products (2)

mRNA Protein Name
NM_001291440.2 NP_001278369.1 DNA repair protein RAD51 homolog 3 isoform 1
NM_053269.4 NP_444499.1 DNA repair protein RAD51 homolog 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables crossover junction DNA endonuclease activity IMP
IMP: Inferred from mutant phenotype
17312021 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19327148 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within female meiosis sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
17312021 MGI
acts upstream of or within male meiosis I IMP
IMP: Inferred from mutant phenotype
17312021 MGI
acts upstream of or within reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
17312021 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
17312021 MGI
involved in telomere maintenance via recombination IGI
IGI: Inferred from genetic interaction
21076401 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19327148 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein RAD51 homolog 3

  • RAD51 homolog C

  • RAD51-like protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11608 RAD51C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad51c NCBI NCBI:5889