Spred2 - sprouty-related EVH1 domain containing 2 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 114716

Summary

Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Spred2 Products (1)

mRNA	Protein	Name
NM_033523.4	NP_277058.1	sprouty-related, EVH1 domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12646235	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20736167	MGI
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	20736167	MGI
enables stem cell factor receptor binding	IPI IPI: Inferred from physical interaction	12646235	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	29501879	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12646235	MGI
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	25576668	MGI
involved in negative regulation of lens fiber cell differentiation	IDA IDA: Inferred from direct assay	29501879	MGI
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	20736167	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	25576668	MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	20736167	MGI
involved in regulation of protein deacetylation	IDA IDA: Inferred from direct assay	20736167	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15580519	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12646235	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sprouty-related, EVH1 domain-containing protein 2	sprouty protein with EVH-1 domain 2, related sequence

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13710	SPRED2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spred2	NCBI	NCBI:200734