Actn2 - actinin alpha 2 Gene

Also Known as 1110008F24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11472

Summary

Enables several functions, including LIM domain binding activity; nuclear receptor coactivator activity; and transmembrane transporter binding activity. Involved in cardiac muscle cell development; positive regulation of transport; and protein localization to plasma membrane. Acts upstream of or within muscle contraction. Located in Z disc. Is expressed in several structures, including alimentary system; heart; limb; musculature; and trunk somite. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Actn2 Products (1)

mRNA	Protein	Name
NM_033268.4	NP_150371.4	alpha-actinin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables LIM domain binding	IPI IPI: Inferred from physical interaction	10391924	MGI
enables actin filament binding	IDA IDA: Inferred from direct assay	15465019	MGI
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	10391924	MGI
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	15072553	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10391924	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19943616	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19815520	MGI
involved in positive regulation of cation channel activity	IMP IMP: Inferred from mutant phenotype	19815520	MGI
involved in positive regulation of endocytic recycling	IMP IMP: Inferred from mutant phenotype	19815520	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19815520	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	15665106	MGI
located in sarcomere	IDA IDA: Inferred from direct assay	16585392	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-actinin-2	F-actin cross-linking protein alpha-actinin skeletal muscle

Actn2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Actn2	Q9JI91	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	16710293
Intra	Actn2	Q9JI91	Camk2a	Mus musculus	P11798	Pull Down	16120608

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00224	ACTN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actn2	NCBI	NCBI:88