1. Gene
  2. SLC25A25 - solute carrier family 25 member 25 Gene

SLC25A25 - solute carrier family 25 member 25 Gene

Homo sapiens

Also known as MCSC; PCSCL; SCAMC2; SCAMC-2

Gene ID: 114789 | Gene type: protein coding

About SLC25A25

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,068,232-128,109,245 (from NCBI)

This gene has 12 transcripts (splice variants), 285 orthologues and 49 paralogues. Ubiquitous expression in liver (RPKM 17.5), gall bladder (RPKM 17.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

SLC25A25 Products(6)

mRNA Protein Name
NM_001006641.4 NP_001006642.1 calcium-binding mitochondrial carrier protein SCaMC-2 isoform b
NM_001006642.4 NP_001006643.1 calcium-binding mitochondrial carrier protein SCaMC-2 isoform c precursor
NM_001265614.3 NP_001252543.1 calcium-binding mitochondrial carrier protein SCaMC-2 isoform 5 precursor
NM_001330988.2 NP_001317917.1 calcium-binding mitochondrial carrier protein SCaMC-2 isoform e
NM_001387057.1 NP_001373986.1 calcium-binding mitochondrial carrier protein SCaMC-2 isoform f
NM_052901.5 NP_443133.2 calcium-binding mitochondrial carrier protein SCaMC-2 isoform a

SLC25A25 Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (55 - 78)

EF-hand_7

EF-hand_7: EF-hand domain pair (83 - 141)

Mito_carr

Mito_carr: Mitochondrial carrier protein (186 - 272)

Mito_carr

Mito_carr: Mitochondrial carrier protein (278 - 364)

Mito_carr

Mito_carr: Mitochondrial carrier protein (375 - 464)

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  • 469 a.a.
Protein Preferred Names Protein Names

calcium-binding mitochondrial carrier protein SCaMC-2

mitochondrial ATP-Mg/Pi carrier protein 3

Related Diseases

Diseases Alias
Nephrolithiasis

Kidney Stones

Stone - Kidney/Ureter

Kidney Calculi

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus SLC25A25 VGNC VGNC:65266
Canis familiaris SLC25A25 VGNC VGNC:46301
Mus musculus SLC25A25 MGD MGI:1915913
Rattus norvegicus SLC25A25 RGD RGD:628666
Bos taurus SLC25A25 VGNC VGNC:34751
Macaca mulatta SLC25A25 VGNC VGNC:77531