Eif2ak4 - eukaryotic translation initiation factor 2 alpha kinase 4 Gene

Rattus norvegicus

Gene ID: 114859 | Gene type: protein coding

About Eif2ak4

Summary

Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in positive regulation of protein phosphorylation. Predicted to be part of polysome. Predicted to be active in cytosol. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak4 Products(1)

mRNA	Protein	Name
NM_001105744.2	NP_001099214.2	eIF-2-alpha kinase GCN2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	32209028	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eIF-2-alpha kinase GCN2

GCN2-like protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148062	RSS0680	Degrader	98.03%	Unkown
HY-W319647	GCN2 activator-1	Inhibitor	99.69%	Unkown
HY-E70712	EIF2AK4 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS04247	EIF2AK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak4	NCBI	NCBI:440275

Name
Email *

	Sorry, but the email address you supplied was invalid.