Eif2ak4 - eukaryotic translation initiation factor 2 alpha kinase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114859

Summary

Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in positive regulation of protein phosphorylation. Predicted to be part of polysome. Predicted to be active in cytosol. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak4 Products (1)

mRNA Protein Name
NM_001105744.2 NP_001099214.2 eIF-2-alpha kinase GCN2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
32209028 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eIF-2-alpha kinase GCN2

  • GCN2-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148062 RSS0680 Degrader 98.03% Unkown
HY-W319647 GCN2 activator-1 Inhibitor 99.69% Unkown
HY-E70712 EIF2AK4 Recombinant Human Active Protein Kinase / Unkown
HY-RS04247 EIF2AK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2ak4 NCBI NCBI:440275