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Cat. No.: HY-208758

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GCN2/GSK3α-IN-1

GCN2/GSK3α-IN-1 is a GCN2 and GSK3α inhibitor with an IC₅₀ of less than 1 μM for both targets. GCN2/GSK3α-IN-1 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1627180-54-4
Formula: C₂₀H₂₀N₈O
Molecular Weight:388.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GCN2/GSK3α-IN-1 Chemical Structure

CAS No.: 1627180-54-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GCN2/GSK3α-IN-1 is a GCN2 and GSK3α inhibitor with an IC₅₀ of less than 1 μM for both targets. GCN2/GSK3α-IN-1 can be used in cancer research^[1].

IC₅₀ & Target^[1]

GSK-3α

<1 μM (IC₅₀)

GCN2

<1 μM (IC₅₀)

All GSK-3 Isoforms :

In Vitro

GCN2/GSK3α-IN-1 (Compound A109) inhibits GSK3α in enzyme-based assays with an IC₅₀ of less than 1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1627180-54-4
Molecular Weight 388.43
Formula C₂₀H₂₀N₈O
SMILES

COC1=CC=C(N2N=NC3=C2N=C(N[C@@H]4CCN(C5=CC=NC=C5)C4)N=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dieter Dorsch, et al. Triazolo[4,5-d]pyrimidine derivatives for the treatment of diseases such as cancer. WO2014135244A1. WIPO (PCT). 2014-02-10.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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GCN2/GSK3α-IN-1

All GSK-3 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GCN2/GSK3α-IN-1 Related Classifications

HY-208758 Related Classifications