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GPRASP2 - G protein-coupled receptor associated sorting protein 2 Gene

Also Known as DFNX7; GASP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114928

About GPRASP2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:102,712,448-102,717,733 (from NCBI)

This gene has 5 transcripts (splice variants), 150 orthologues, 11 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 5.6), ovary (RPKM 5.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 Muscarinic Acetylcholine Receptor and the Calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GPRASP2 Products (5)

mRNA	Protein	Name
NM_001004051.4	NP_001004051.1	G-protein coupled receptor-associated sorting protein 2
NM_001184874.3	NP_001171803.1	G-protein coupled receptor-associated sorting protein 2
NM_001184875.3	NP_001171804.1	G-protein coupled receptor-associated sorting protein 2
NM_001184876.3	NP_001171805.1	G-protein coupled receptor-associated sorting protein 2
NM_138437.6	NP_612446.1	G-protein coupled receptor-associated sorting protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	15086532	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15383276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRASP2 Protein Structure

Arm_2

0
200
400
600
800
838 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor-associated sorting protein 2

Related Diseases

Diseases	Alias
Deafness, X-Linked 7	X-Linked External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome DFNX7 X-Linked Deafness 7 Deafness, X-Linked, 7
Extratemporal Epilepsy
Autosomal Dominant Nonsyndromic Deafness 74	Dfna74
Deafness, X-Linked 4	DFNX4 Dfn6 Deafness, Nonsyndromic Sensorineural Progressive 6 X-Linked Deafness 4 Deafness, X-Linked 6, Progressive Nonsyndromic Sensorineural Progressive Deafness 6 X-Linked Progressive Deafness 6 Deafness, X-Linked, 4 Deafness Nonsyndromic Sensorineural Progressive 6 Deafness X-Linked 6 Progressive Deafness, X-Linked, Type 4
Deafness, X-Linked 5, With Peripheral Neuropathy	Deafness, X-Linked 5 DFNX5 Aunx1 Auditory Neuropathy, X-Linked, 1, With Peripheral Sensory Neuropathy X-Linked Deafness 5 X-Linked Auditory Neuropathy With Peripheral Sensory Neuropathy Type 1 X-Linked Hsan With Deafness X-Linked Auditory Neuropathy 1 With Peripheral Sensory Neuropathy X-Linked Hereditary Sensory And Autonomic Neuropathy With Deafness X-Linked Hsan With Hearing Loss X-Linked Hereditary Sensory And Autonomic Neuropathy With Hearing Loss Deafness, X-Linked, 5, With Peripheral Neuropathy Deafness, X-Linked, Type 5
Basal Cell Carcinoma, Infundibulocystic	Basal Cell Carcinoma With Follicular Differentiation Infundibulocystic Basal Cell Carcinoma Skin Infundibulocystic Basal Cell Carcinoma
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Deafness, X-Linked 2	Progressive Deafness With Stapes Fixation DFNX2 Dfn3 Nance Deafness Perilymphatic Gusher-Deafness Syndrome Stapedo-Vestibular Ankylosis Sensorineural Deafness, Profound, With Or Without A Conductive Component, Associated With A Unique Developmental Abnormality Of The Ear X-Linked Deafness 2 X-Linked Mixed Conductive And Neurosensory Deafness X-Linked Mixed Conductive And Sensorineural Deafness Deafness 3 Conductive With Stapes Fixation Deafness Conductive With Stapes Fixation Deafness Mixed With Perilymphatic Gusher Thies-Reis Syndrome Deafness, Conductive, With Stapes Fixation Deafness 3, Conductive, With Stapes Fixation Deafness, Mixed, With Perilymphatic Gusher Conductive Deafness 3 With Stapes Fixation Conductive Deafness With Stapes Fixation Mixed Deafness With Perilymphatic Gusher X-Linked Deafness Type 2 X-Linked Mixed Conductive And Neurosensory Hearing Loss X-Linked Mixed Conductive And Sensorineural Hearing Loss X-Linked Sensorineural Deafness X-Linked Stapes Gusher Syndrome Deafness Mixed With Perilymphatic Gusher, X-Linked Dfn 3 Nonsyndromic Hearing Loss And Deafness Gusher Syndrome Thies Reis Syndrome Progressive Hearing Loss With Stapes Fixation Deafness, X-Linked, 2 Deafness Mixed With Perilymph Gusher X-Linked Deafness, X-Linked, Type 2 Progressive Hearing Loss Stapes Fixation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.83%	Unkown
HY-P1208	PG-931	Agonist	99.60%	Unkown
HY-RS05748	GPRASP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPRASP2	VGNC	VGNC:41449
Bos taurus	GPRASP2	VGNC	VGNC:29605
Felis catus	GPRASP2	VGNC	VGNC:82381
Mus musculus	GPRASP2	MGD	MGI:2442071
Rattus norvegicus	GPRASP2	RGD	RGD:1561019
Macaca mulatta	GPRASP2	VGNC	VGNC:73006
Others	GPRASP2	NCBI