2. Gene
  3. GPRASP2 - G protein-coupled receptor associated sorting protein 2 Gene

GPRASP2 - G protein-coupled receptor associated sorting protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DFNX7; GASP2

Gene ID: 114928 | Gene type: protein coding

About GPRASP2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:102,712,448-102,717,733 (from NCBI)

This gene has 5 transcripts (splice variants), 150 orthologues, 11 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 5.6), ovary (RPKM 5.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 Muscarinic Acetylcholine Receptor and the Calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GPRASP2 Products(5)

mRNA Protein Name
NM_001004051.4 NP_001004051.1 G-protein coupled receptor-associated sorting protein 2
NM_001184874.3 NP_001171803.1 G-protein coupled receptor-associated sorting protein 2
NM_001184875.3 NP_001171804.1 G-protein coupled receptor-associated sorting protein 2
NM_001184876.3 NP_001171805.1 G-protein coupled receptor-associated sorting protein 2
NM_138437.6 NP_612446.1 G-protein coupled receptor-associated sorting protein 2

GPRASP2 Protein Structure

Arm_2

Arm_2: Armadillo-like (593 - 836)

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  • 600
  • 838 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor-associated sorting protein 2

Related Diseases

Diseases Alias
Deafness, X-Linked 7

X-Linked External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome

DFNX7

X-Linked Deafness 7

Deafness, X-Linked, 7
Extratemporal Epilepsy
Autosomal Dominant Nonsyndromic Deafness 74

Dfna74
Deafness, X-Linked 4

DFNX4

Dfn6

Deafness, Nonsyndromic Sensorineural Progressive 6

X-Linked Deafness 4

Deafness, X-Linked 6, Progressive

Nonsyndromic Sensorineural Progressive Deafness 6

X-Linked Progressive Deafness 6

Deafness, X-Linked, 4

Deafness Nonsyndromic Sensorineural Progressive 6

Deafness X-Linked 6 Progressive

Deafness, X-Linked, Type 4
Deafness, X-Linked 5, With Peripheral Neuropathy

Deafness, X-Linked 5

DFNX5

Aunx1

Auditory Neuropathy, X-Linked, 1, With Peripheral Sensory Neuropathy

X-Linked Deafness 5

X-Linked Auditory Neuropathy With Peripheral Sensory Neuropathy Type 1

X-Linked Hsan With Deafness

X-Linked Auditory Neuropathy 1 With Peripheral Sensory Neuropathy

X-Linked Hereditary Sensory And Autonomic Neuropathy With Deafness

X-Linked Hsan With Hearing Loss

X-Linked Hereditary Sensory And Autonomic Neuropathy With Hearing Loss

Deafness, X-Linked, 5, With Peripheral Neuropathy

Deafness, X-Linked, Type 5
Basal Cell Carcinoma, Infundibulocystic

Basal Cell Carcinoma With Follicular Differentiation

Infundibulocystic Basal Cell Carcinoma

Skin Infundibulocystic Basal Cell Carcinoma
Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris
Deafness, X-Linked 2

Progressive Deafness With Stapes Fixation

DFNX2

Dfn3

Nance Deafness

Perilymphatic Gusher-Deafness Syndrome

Stapedo-Vestibular Ankylosis

Sensorineural Deafness, Profound, With Or Without A Conductive Component, Associated With A Unique Developmental Abnormality Of The Ear

X-Linked Deafness 2

X-Linked Mixed Conductive And Neurosensory Deafness

X-Linked Mixed Conductive And Sensorineural Deafness

Deafness 3 Conductive With Stapes Fixation

Deafness Conductive With Stapes Fixation

Deafness Mixed With Perilymphatic Gusher

Thies-Reis Syndrome

Deafness, Conductive, With Stapes Fixation

Deafness 3, Conductive, With Stapes Fixation

Deafness, Mixed, With Perilymphatic Gusher

Conductive Deafness 3 With Stapes Fixation

Conductive Deafness With Stapes Fixation

Mixed Deafness With Perilymphatic Gusher

X-Linked Deafness Type 2

X-Linked Mixed Conductive And Neurosensory Hearing Loss

X-Linked Mixed Conductive And Sensorineural Hearing Loss

X-Linked Sensorineural Deafness

X-Linked Stapes Gusher Syndrome

Deafness Mixed With Perilymphatic Gusher, X-Linked

Dfn 3 Nonsyndromic Hearing Loss And Deafness

Gusher Syndrome

Thies Reis Syndrome

Progressive Hearing Loss With Stapes Fixation

Deafness, X-Linked, 2

Deafness Mixed With Perilymph Gusher X-Linked

Deafness, X-Linked, Type 2

Progressive Hearing Loss Stapes Fixation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0227 SHU 9119 99.95% Unkown
HY-RS05748 GPRASP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPRASP2 VGNC VGNC:41449
Bos taurus GPRASP2 VGNC VGNC:29605
Felis catus GPRASP2 VGNC VGNC:82381
Mus musculus GPRASP2 MGD MGI:2442071
Rattus norvegicus GPRASP2 RGD RGD:1561019
Macaca mulatta GPRASP2 VGNC VGNC:73006