Adam22 - a disintegrin and metallopeptidase domain 22 Gene

Mus musculus

Also known as MDC2; 2900022I03Rik

Gene ID: 11496 | Gene type: protein coding

About Adam22

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]

Adam22 Products(5)

mRNA	Protein	Name
NM_001007220.3	NP_001007221.1	disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor
NM_001007221.3	NP_001007222.1	disintegrin and metalloproteinase domain-containing protein 22 isoform b precursor
NM_001098225.2	NP_001091695.1	disintegrin and metalloproteinase domain-containing protein 22 isoform c precursor
NM_001310439.1	NP_001297368.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor
NM_001310440.1	NP_001297369.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 5 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16990550	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Schwann cell differentiation	IMP IMP: Inferred from mutant phenotype	15876356	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	15876356	MGI
acts upstream of or within gliogenesis	IGI IGI: Inferred from genetic interaction	21068328	MGI
acts upstream of or within myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	15876356	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	16990550	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	16990550	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	20089912	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16990550	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16990550	MGI
located in membrane	IDA IDA: Inferred from direct assay	20089912	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	16990550	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	16990550	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 22

a disintegrin and metalloprotease domain (ADAM) 22

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00278	ADAM22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam22	NCBI	NCBI:53616

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