Adam3 - a disintegrin and metallopeptidase domain 3 (cyritestin) Gene

Also Known as tMDC; Cyrn1; Taz83

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11497

Summary

Predicted to enable metalloendopeptidase activity. Involved in fertilization and flagellated sperm motility. Acts upstream of or within binding activity of sperm to zona pellucida; positive regulation of gene expression; and regulation of mRNA processing. Located in several cellular components, including cell surface; membrane raft; and sperm head. Part of protein-containing complex. Human ortholog(s) of this gene implicated in brain glioma and conjunctival squamous cell carcinoma. Orthologous to human ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

Adam3 Products (2)

mRNA Protein Name
NM_001324489.1 NP_001311418.1 A disintegrin and metallopeptidase domain 3 isoform 2
NM_009619.5 NP_033749.2 A disintegrin and metallopeptidase domain 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22357757 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
16330764 MGI
acts upstream of or within binding of sperm to zona pellucida IMP
IMP: Inferred from mutant phenotype
15194697 MGI
involved in fertilization IMP
IMP: Inferred from mutant phenotype
19339711 MGI
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
19339711 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16407499 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19129510 MGI
acts upstream of or within regulation of mRNA processing IMP
IMP: Inferred from mutant phenotype
19129510 MGI
acts upstream of or within single fertilization IGI
IGI: Inferred from genetic interaction
22621904 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell surface IDA
IDA: Inferred from direct assay
16407499 MGI
located in cell surface IDA
IDA: Inferred from direct assay
15194697 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
15194697 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15514464 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19129510 MGI
located in sperm head IDA
IDA: Inferred from direct assay
15514464 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metallopeptidase domain 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00282 ADAM30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00283 ADAM32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00284 ADAM33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19049 Adam32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19499 Adam30 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20134 Adam33 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25539 Adam32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25993 Adam30 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26637 Adam33 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown