Adcy8 - adenylate cyclase 8 Gene

Also Known as AC8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11514

Summary

Enables calcium- and calmodulin-responsive Adenylate Cyclase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to morphine; and regulation of synaptic plasticity. Acts upstream of or within long-term memory. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and postsynaptic density. Is integral component of presynaptic membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY8 (Adenylate Cyclase 8). [provided by Alliance of Genome Resources, Apr 2022]

Adcy8 Products (3)

mRNA Protein Name
NM_001291903.1 NP_001278832.1 adenylate cyclase type 8 isoform 2
NM_001331075.1 NP_001318004.1 adenylate cyclase type 8 isoform 3
NM_009623.2 NP_033753.2 adenylate cyclase type 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenylate cyclase activity IGI
IGI: Inferred from genetic interaction
10482244 MGI
enables adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
10799557 MGI
enables calcium- and calmodulin-responsive adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
10864938 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20410303 MGI
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9075801 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25403481 MGI
involved in cellular response to glucagon stimulus IDA
IDA: Inferred from direct assay
23292513 MGI
involved in cellular response to morphine IMP
IMP: Inferred from mutant phenotype
18222416 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
25403481 MGI
involved in glucose mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
25403481 MGI
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
18222416 MGI
acts upstream of or within long-term memory IGI
IGI: Inferred from genetic interaction
10482244 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
18448650 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
10482244 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10482244 MGI
involved in neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
12441059 MGI
involved in positive regulation of CREB transcription factor activity IMP
IMP: Inferred from mutant phenotype
10864938 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
9075801 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
25403481 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
25403481 MGI
involved in positive regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
10864938 MGI
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
10482244 MGI
involved in positive regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
14585998 MGI
involved in regulation of cellular response to stress IMP
IMP: Inferred from mutant phenotype
12206999 MGI
involved in regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
25403481 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
10482244 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
10482244 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14585998 MGI
located in axon IDA
IDA: Inferred from direct assay
14585998 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
14585998 MGI
located in dendrite IDA
IDA: Inferred from direct assay
14585998 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
14585998 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10482244 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
10482244 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
14585998 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
14585998 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
14585998 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
23292513 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17335981 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
17335981 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
17335981 MGI
is active in presynaptic membrane IEP
IEP: Inferred from expression pattern
17335981 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate cyclase type 8

  • ATP pyrophosphate-lyase 8

  • adenylate cyclase type VIII

  • adenylyl cyclase 8

  • ca(2+)/calmodulin-activated adenylyl cyclase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00334 ADCY8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adcy8 NCBI NCBI:114