Adcy8 - adenylate cyclase 8 Gene

Mus musculus

Also known as AC8

Gene ID: 11514 | Gene type: protein coding

About Adcy8

Summary

Enables calcium- and calmodulin-responsive Adenylate Cyclase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to morphine; and regulation of synaptic plasticity. Acts upstream of or within long-term memory. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and postsynaptic density. Is integral component of presynaptic membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY8 (Adenylate Cyclase 8). [provided by Alliance of Genome Resources, Apr 2022]

Adcy8 Products(3)

mRNA	Protein	Name
NM_001291903.1	NP_001278832.1	adenylate cyclase type 8 isoform 2
NM_001331075.1	NP_001318004.1	adenylate cyclase type 8 isoform 3
NM_009623.2	NP_033753.2	adenylate cyclase type 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase activity	IGI IGI: Inferred from genetic interaction	10482244	MGI
enables adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	10799557	MGI
enables calcium- and calmodulin-responsive adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	10864938	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20410303	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9075801	MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25403481	MGI
involved in cellular response to glucagon stimulus	IDA IDA: Inferred from direct assay	23292513	MGI
involved in cellular response to morphine	IMP IMP: Inferred from mutant phenotype	18222416	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	25403481	MGI
involved in glucose mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	25403481	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	18222416	MGI
acts upstream of or within long-term memory	IGI IGI: Inferred from genetic interaction	10482244	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	18448650	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	10482244	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	10482244	MGI
involved in neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	12441059	MGI
involved in positive regulation of CREB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10864938	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	9075801	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	25403481	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	25403481	MGI
involved in positive regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	10864938	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	10482244	MGI
involved in positive regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	14585998	MGI
involved in regulation of cellular response to stress	IMP IMP: Inferred from mutant phenotype	12206999	MGI
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	25403481	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	10482244	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	10482244	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14585998	MGI
located in axon	IDA IDA: Inferred from direct assay	14585998	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	14585998	MGI
located in dendrite	IDA IDA: Inferred from direct assay	14585998	MGI
located in excitatory synapse	IDA IDA: Inferred from direct assay	14585998	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10482244	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10482244	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	14585998	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	14585998	MGI
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	14585998	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	23292513	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17335981	MGI
located in presynaptic active zone	IDA IDA: Inferred from direct assay	17335981	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	17335981	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	17335981	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenylate cyclase type 8

ATP pyrophosphate-lyase 8	adenylate cyclase type VIII
adenylyl cyclase 8	ca(2+)/calmodulin-activated adenylyl cyclase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00334	ADCY8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcy8	NCBI	NCBI:114

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