Adra1b - adrenergic receptor, alpha 1b Gene

Mus musculus

Also known as [a]1b

Gene ID: 11548 | Gene type: protein coding

About Adra1b

Summary

Enables alpha1-adrenergic receptor activity. Involved in multicellular organism aging; neuron-glial cell signaling; and regulation of blood pressure. Acts upstream of or within several processes, including positive regulation of blood pressure; regulation of glycogen catabolic process; and response to alkaloid. Is integral component of membrane. Is expressed in central nervous system; heart; retina; and testis. Orthologous to human ADRA1B (adrenoceptor alpha 1B). [provided by Alliance of Genome Resources, Apr 2022]

Adra1b Products(3)

mRNA	Protein	Name
NM_001284380.1	NP_001271309.1	alpha-1B adrenergic receptor
NM_001284381.1	NP_001271310.1	alpha-1B adrenergic receptor
NM_007416.4	NP_031442.2	alpha-1B adrenergic receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha1-adrenergic receptor activity	IDA IDA: Inferred from direct assay	7911220	MGI
enables alpha1-adrenergic receptor activity	IGI IGI: Inferred from genetic interaction	12782680	MGI
enables alpha1-adrenergic receptor activity	IMP IMP: Inferred from mutant phenotype	9326654	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult heart development	IGI IGI: Inferred from genetic interaction	12782680	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	11923452	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	15231500	MGI
acts upstream of or within cell growth involved in cardiac muscle cell development	IGI IGI: Inferred from genetic interaction	12782680	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	14581480	MGI
acts upstream of glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	14581480	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	11222061	MGI
acts upstream of or within negative regulation of glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	14581480	MGI
involved in neuron-glial cell signaling	IGI IGI: Inferred from genetic interaction	10493741	MGI
acts upstream of or within organ growth	IGI IGI: Inferred from genetic interaction	12782680	MGI
acts upstream of or within positive regulation of glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	14581480	MGI
acts upstream of or within positive regulation of heart rate by epinephrine-norepinephrine	IGI IGI: Inferred from genetic interaction	12782680	MGI
acts upstream of or within positive regulation of the force of heart contraction by epinephrine-norepinephrine	IGI IGI: Inferred from genetic interaction	12595294	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	26531127	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	11923452	MGI
acts upstream of or within response to morphine	IMP IMP: Inferred from mutant phenotype	11923452	MGI
acts upstream of or within vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	9326654	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	11222061	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	11923452	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-1B adrenergic receptor

alpha-1B adrenoceptor	alpha-1B adrenoreceptor
alpha1B-adrenergic receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00409	ADRA1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adra1b	NCBI	NCBI:147

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