Adrb3 - adrenergic receptor, beta 3 Gene

Also Known as Adrb-3; beta 3-AR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11556

Summary

Enables beta-3 Adrenergic Receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Located in membrane. Is expressed in central nervous system; early conceptus; oocyte; and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; obesity; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Adrb3 Products (1)

mRNA Protein Name
NM_013462.3 NP_038490.2 beta-3 adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-3 adrenergic receptor binding IDA
IDA: Inferred from direct assay
7738011 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7738011 MGI
acts upstream of or within brown fat cell differentiation IGI
IGI: Inferred from genetic interaction
12387862 MGI
acts upstream of or within diet induced thermogenesis IGI
IGI: Inferred from genetic interaction
12161655 MGI
acts upstream of or within heat generation IGI
IGI: Inferred from genetic interaction
12161655 MGI
acts upstream of or within negative regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
12387862 MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
10358009 MGI
involved in positive regulation of cold-induced thermogenesis IGI
IGI: Inferred from genetic interaction
12387862 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
7493988 MGI
acts upstream of or within response to cold IGI
IGI: Inferred from genetic interaction
12161655 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
7738011 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-3 adrenergic receptor

  • Beta-3 AR

  • beta-3 adrenoceptor

  • beta-3 adrenoreceptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00416 ADRB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19404 Adrb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25896 Adrb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adrb3 NCBI NCBI:155