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GRIN3A - glutamate ionotropic receptor NMDA type subunit 3A Gene

Also Known as NR3A; GluN3A; NMDAR-L; NMDAR3A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116443

About GRIN3A

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,569,352-101,738,647 (from NCBI)

This gene has 2 transcripts (splice variants), 245 orthologues and 17 paralogues. Biased expression in brain (RPKM 4.0), prostate (RPKM 0.5) and 3 other tissues.

Summary

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA Receptor activity. [provided by RefSeq, Jul 2008]

GRIN3A Products (1)

mRNA	Protein	Name
NM_133445.3	NP_597702.2	glutamate receptor ionotropic, NMDA 3A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	17502428	GOA
enables glycine binding	IDA IDA: Inferred from direct assay	17320117	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17997397	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17658481	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to ethanol	IDA IDA: Inferred from direct assay	17502428	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	17997397	GOA
located in membrane	IDA IDA: Inferred from direct assay	17997397	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	17658481	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	17658481	GOA
located in synapse	IDA IDA: Inferred from direct assay	17658481	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIN3A Protein Structure

SBP_bac_3

Lig_chan

0
200
400
600
800
1000
1115 a.a.

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, NMDA 3A	N-methyl-D-aspartate receptor subtype 3A

Related Diseases

Diseases	Alias
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Depersonalization Disorder	Neurotic Derealization Depersonalization Depersonalization/Derealization Disorder Depersonalisation-Derealization Syndrome Depersonalisation Disorder Depersonalisation Neurosis Depersonalisation Syndrome Feeling Of Unreality Feels Own Self Is Unreal Neurotic State With Depersonalisation Neurotic State With Depersonalization Episode
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05806	GRIN3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GRIN3A	MGD	MGI:1933206
Canis familiaris	GRIN3A	VGNC	VGNC:41496
Felis catus	GRIN3A	VGNC	VGNC:62713
Bos taurus	GRIN3A	VGNC	VGNC:29650
Macaca mulatta	GRIN3A	VGNC	VGNC:73177
Rattus norvegicus	GRIN3A	RGD	RGD:621704
Others	GRIN3A	NCBI