Sacm1l - SAC1 like phosphatidylinositide phosphatase Gene

Also Known as Sac1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116482

Summary

This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide Phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]

Sacm1l Products (2)

mRNA	Protein	Name
NM_001357497.1	NP_001344426.1	phosphatidylinositol-3-phosphatase SAC1 isoform 1x
NM_053798.3	NP_446250.1	phosphatidylinositol-3-phosphatase SAC1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatase activity	IMP IMP: Inferred from mutant phenotype	10887188	RGD
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10887188	RGD
enables phosphatidylinositol-3-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	10887188	RGD
enables phosphatidylinositol-4-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	10887188	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in neurotransmitter receptor transport to postsynaptic membrane	EXP EXP: Inferred from Experiment	23838184	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IDA IDA: Inferred from direct assay	23838184	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IEP IEP: Inferred from expression pattern	23838184	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	23838184	RGD
involved in phosphatidylinositol dephosphorylation	IMP IMP: Inferred from mutant phenotype	10887188	RGD
involved in vesicle-mediated transport in synapse	EXP EXP: Inferred from Experiment	23838184	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	23838184	RGD
involved in vesicle-mediated transport in synapse	IEP IEP: Inferred from expression pattern	23838184	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	23838184	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10887188	RGD
located in endoplasmic reticulum-plasma membrane contact site	IDA IDA: Inferred from direct assay	27044890	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23838184	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23838184	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23838184	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositol-3-phosphatase SAC1	SAC1 suppressor of actin mutations 1-like phosphatidylinositide phosphatase SAC1 phosphatidylinositol-4-phosphate phosphatase suppressor of actin mutations 1-like protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12410	SACM1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sacm1l	NCBI	NCBI:22908