Gripap1 - GRIP1 associated protein 1 Gene

Rattus norvegicus

Also known as Grasp1

Gene ID: 116493 | Gene type: protein coding

About Gripap1

Summary

Predicted to enable identical protein binding activity. Involved in neurotransmitter receptor transport, endosome to postsynaptic membrane; regulation of intracellular transport; and regulation of modification of synaptic structure. Located in postsynaptic recycling endosome. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic early endosome membrane. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Gripap1 Products(1)

mRNA	Protein	Name
NM_053807.2	NP_446259.1	GRIP1-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	10896157	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	10896157	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10896157	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein localization	IMP IMP: Inferred from mutant phenotype	10896157	RGD
involved in negative regulation of receptor clustering	IMP IMP: Inferred from mutant phenotype	10896157	RGD
involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	20098723	RGD
involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	20098723	RGD
involved in regulation of recycling endosome localization within postsynapse	IDA IDA: Inferred from direct assay	20098723	RGD
involved in regulation of recycling endosome localization within postsynapse	IMP IMP: Inferred from mutant phenotype	20098723	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	10896157	RGD
is active in extrinsic component of postsynaptic early endosome membrane	IDA IDA: Inferred from direct assay	20098723	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20098723	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20098723	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10896157	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	10896157	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GRIP1-associated protein 1

GRASP-1

GRIP-associated protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05811	GRIPAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gripap1	NCBI	NCBI:56850

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