Nherf2 - NHERF family PDZ scaffold protein 2 Gene

Also Known as E3karp; Slc9a3r2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116501

Summary

Enables low-density lipoprotein particle receptor binding activity; molecular adaptor activity; and protein N-terminus binding activity. Involved in inner ear development and positive regulation of ion transmembrane transport. Located in apical plasma membrane and nucleus. Part of protein-containing complex. Biomarker of hypertension. Orthologous to human SLC9A3R2 (SLC9A3 regulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Nherf2 Products (1)

mRNA Protein Name
NM_053811.3 NP_446263.2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
22349218 RGD
enables molecular adaptor activity IMP
IMP: Inferred from mutant phenotype
22349218 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11457882 RGD
Biological Process GO Annotation Evidence References Source
involved in inner ear development IEP
IEP: Inferred from expression pattern
16160858 RGD
involved in positive regulation of monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
16234233 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11457882 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
22349218 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

  • NHE3 kinase A regulatory protein E3KARP

  • NHERF-2

  • SIP-1

  • SLC9A3 regulator 2

  • SRY-interacting protein 1

  • TKA-1

  • sodium-hydrogen exchanger regulatory factor 2

  • sodium/hydrogen exchanger

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulato

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09283 NHERF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nherf2 NCBI NCBI:9351