Nherf2 - NHERF family PDZ scaffold protein 2 Gene

Rattus norvegicus

Also known as E3karp; Slc9a3r2

Gene ID: 116501 | Gene type: protein coding

About Nherf2

Summary

Enables low-density lipoprotein particle receptor binding activity; molecular adaptor activity; and protein N-terminus binding activity. Involved in inner ear development and positive regulation of ion transmembrane transport. Located in apical plasma membrane and nucleus. Part of protein-containing complex. Biomarker of hypertension. Orthologous to human SLC9A3R2 (SLC9A3 regulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Nherf2 Products(1)

mRNA	Protein	Name
NM_053811.3	NP_446263.2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	22349218	RGD
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	22349218	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11457882	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in inner ear development	IEP IEP: Inferred from expression pattern	16160858	RGD
involved in positive regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	16234233	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11457882	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	22349218	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

NHE3 kinase A regulatory protein E3KARP	NHERF-2
SIP-1	SLC9A3 regulator 2
SRY-interacting protein 1	TKA-1
sodium-hydrogen exchanger regulatory factor 2	sodium/hydrogen exchanger
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulato

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09283	NHERF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nherf2	NCBI	NCBI:9351

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