Pcsk5 - proprotein convertase subtilisin/kexin type 5 Gene

Rattus norvegicus

Also known as PC6; Pc5

Gene ID: 116548 | Gene type: protein coding

About Pcsk5

Summary

Predicted to enable peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of integrin-mediated signaling pathway; and positive regulation of smooth muscle cell-matrix adhesion. Located in several cellular components, including Golgi apparatus subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk5 Products(1)

mRNA	Protein	Name
NM_053823.1	NP_446275.1	proprotein convertase subtilisin/kexin type 5 preproprotein

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	11882580	RGD
involved in positive regulation of integrin activation	IMP IMP: Inferred from mutant phenotype	14970114	RGD
involved in positive regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	14970114	RGD
involved in positive regulation of smooth muscle cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	14970114	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	14970114	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	18502031	RGD
involved in response to luteinizing hormone	IEP IEP: Inferred from expression pattern	18502031	RGD
involved in vascular associated smooth muscle cell proliferation	IEP IEP: Inferred from expression pattern	11181735	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi medial cisterna	IDA IDA: Inferred from direct assay	10906713	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10408612	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	10408612	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	11882580	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proprotein convertase subtilisin/kexin type 5

proprotein convertase 6

subtilisin/kexin-like protease PC5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10174	PCSK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcsk5	NCBI	NCBI:5125

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