Pcsk5 - proprotein convertase subtilisin/kexin type 5 Gene

Also Known as PC6; Pc5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116548

Summary

Predicted to enable peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of integrin-mediated signaling pathway; and positive regulation of smooth muscle cell-matrix adhesion. Located in several cellular components, including Golgi apparatus subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk5 Products (1)

mRNA Protein Name
NM_053823.1 NP_446275.1 proprotein convertase subtilisin/kexin type 5 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
11882580 RGD
involved in positive regulation of integrin activation IMP
IMP: Inferred from mutant phenotype
14970114 RGD
involved in positive regulation of integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
14970114 RGD
involved in positive regulation of smooth muscle cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
14970114 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
14970114 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
18502031 RGD
involved in response to luteinizing hormone IEP
IEP: Inferred from expression pattern
18502031 RGD
involved in vascular associated smooth muscle cell proliferation IEP
IEP: Inferred from expression pattern
11181735 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi medial cisterna IDA
IDA: Inferred from direct assay
10906713 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
10408612 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
10408612 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
11882580 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proprotein convertase subtilisin/kexin type 5

  • proprotein convertase 6

  • subtilisin/kexin-like protease PC5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10174 PCSK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk5 NCBI NCBI:5125