Atp2a1 - ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Gene

Also Known as Serca1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116601

Summary

Enables several functions, including ATP binding activity; P-type calcium transporter activity; and calcium-dependent ATPase activity. Involved in calcium ion transmembrane transport; response to peptide hormone; and sarcoplasmic reticulum calcium ion transport. Acts upstream of or within calcium ion transport. Located in sarcoplasmic reticulum. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2a1 Products (1)

mRNA Protein Name
NM_058213.2 NP_478120.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12409282 RGD
enables P-type calcium transporter activity IDA
IDA: Inferred from direct assay
9843705 RGD
enables calcium ion binding IDA
IDA: Inferred from direct assay
12409282 RGD
enables calcium-dependent ATPase activity IDA
IDA: Inferred from direct assay
9843705 RGD
enables nucleotide-sugar transmembrane transporter activity IDA
IDA: Inferred from direct assay
12409282 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9295312 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
9843705 RGD
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
9887021 RGD
involved in calcium ion transport IDA
IDA: Inferred from direct assay
12222829 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
9295312 RGD
involved in sarcoplasmic reticulum calcium ion transport IDA
IDA: Inferred from direct assay
19029185 RGD
Cellular Component GO Annotation Evidence References Source
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
8447366 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sarcoplasmic/endoplasmic reticulum calcium ATPase 1

  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

  • SR Ca(2+)-ATPase 1

  • calcium pump 1

  • endoplasmic reticulum class 1/2 Ca(2+) ATPase

  • sarco/endoplasmic reticulum calcium ATPase 1

  • sarco/endoplasmic reticulum calcium ATPase 1a

  • sarco/endoplasmic ret

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01191 ATP2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01194 ATP2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01198 ATP2C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20524 Atp2b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27033 Atp2b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2a1 NCBI NCBI:487