Akap8 - A-kinase anchoring protein 8 Gene

Also Known as Akap95

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116633

Summary

Enables double-stranded DNA binding activity; protein kinase A regulatory subunit binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of tumor necrosis factor production; and regulation of histone modification. Predicted to act upstream of or within mitotic chromosome condensation. Located in Golgi apparatus; mitochondrion; and nuclear matrix. Orthologous to human AKAP8 (A-kinase anchoring protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Akap8 Products (1)

mRNA Protein Name
NM_053855.1 NP_446307.1 A-kinase anchor protein 8

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8125992 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
8125992 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11279182 RGD
enables protein kinase A regulatory subunit binding IDA
IDA: Inferred from direct assay
8125992 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
8125992 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear matrix IDA
IDA: Inferred from direct assay
8125992 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 8

  • A kinase (PRKA) anchor protein 8

  • A-kinase anchor protein 95 kDa

  • AKAP 95

  • AKAP-8

Akap8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Akap8 Q63014 Ddx5 Mus musculus Q61656
Y2H
11279182
Cross
Akap8 Q63014 Ddx5 Mus musculus Q61656
Anti Bait CoIP
11279182
Cross
Akap8 Q63014 Ddx5 Mus musculus Q61656
Far-WB
11279182
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00523 AKAP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00524 AKAP8L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akap8 NCBI NCBI:10270