Exoc4 - exocyst complex component 4 Gene

Also Known as ALR; Sec8; Sec8l1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116654

Summary

Enables PDZ domain binding activity. Involved in several processes, including Golgi to transport vesicle transport; oligodendrocyte differentiation; and positive regulation of calcium-mediated signaling. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Part of protein-containing complex. Is active in synaptic vesicle. Colocalizes with Golgi apparatus and endosome. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Apr 2022]

Exoc4 Products (1)

mRNA Protein Name
NM_053875.1 NP_446327.1 exocyst complex component 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
12675619 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
12738960 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
20956289 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12675619 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16478790 RGD
Biological Process GO Annotation Evidence References Source
involved in Golgi to transport vesicle transport IDA
IDA: Inferred from direct assay
16478790 RGD
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16601687 RGD
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
19383721 RGD
involved in membrane biogenesis IMP
IMP: Inferred from mutant phenotype
16478790 RGD
involved in oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16478790 RGD
involved in positive regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
10973998 RGD
involved in protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
12738960 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12738960 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
12738960 RGD
involved in regulation of protein transport IMP
IMP: Inferred from mutant phenotype
12738960 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
12738960 RGD
located in cell leading edge IDA
IDA: Inferred from direct assay
21658605 RGD
located in dendrite IDA
IDA: Inferred from direct assay
20956289 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
12738960 RGD
located in endosome IDA
IDA: Inferred from direct assay
16478790 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12738960 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
12738960 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12738960 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
12738960 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
12738960 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19885391 RGD
located in synapse IDA
IDA: Inferred from direct assay
12738960 RGD
is active in synaptic vesicle EXP
EXP: Inferred from Experiment
17110340 RGD
is active in synaptic vesicle IDA
IDA: Inferred from direct assay
17110340 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exocyst complex component 4

  • SEC8-like 1

  • augmenter of liver regeneration (ALR) pseudogene

  • exocyst complex component Sec8

  • rSec8

  • secretory protein SEC8

Exoc4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Exoc4 Q62824 WWC1 Homo sapiens Q8IX03-1
Anti Bait CoIP
19885391
Cross
Exoc4 Q62824 WWC1 Homo sapiens Q8IX03-1
Anti Tag CoIP
19885391
Intra
Exoc4 Q62824 Prkci Rattus norvegicus F1M7Y5
Anti Bait CoIP
19885391
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04590 EXOC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Exoc4 NCBI NCBI:60412