Exoc4 - exocyst complex component 4 Gene

Rattus norvegicus

Also known as ALR; Sec8; Sec8l1

Gene ID: 116654 | Gene type: protein coding

About Exoc4

Summary

Enables PDZ domain binding activity. Involved in several processes, including Golgi to transport vesicle transport; oligodendrocyte differentiation; and positive regulation of calcium-mediated signaling. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Part of protein-containing complex. Is active in synaptic vesicle. Colocalizes with Golgi apparatus and endosome. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Apr 2022]

Exoc4 Products(1)

mRNA	Protein	Name
NM_053875.1	NP_446327.1	exocyst complex component 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	12675619	RGD
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	12738960	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	20956289	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12675619	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16478790	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to transport vesicle transport	IDA IDA: Inferred from direct assay	16478790	RGD
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16601687	RGD
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	19383721	RGD
involved in membrane biogenesis	IMP IMP: Inferred from mutant phenotype	16478790	RGD
involved in oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16478790	RGD
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	10973998	RGD
involved in protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	12738960	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12738960	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	12738960	RGD
involved in regulation of protein transport	IMP IMP: Inferred from mutant phenotype	12738960	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	12738960	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	21658605	RGD
located in dendrite	IDA IDA: Inferred from direct assay	20956289	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	12738960	RGD
located in endosome	IDA IDA: Inferred from direct assay	16478790	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12738960	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	12738960	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12738960	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	12738960	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	12738960	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19885391	RGD
located in synapse	IDA IDA: Inferred from direct assay	12738960	RGD
is active in synaptic vesicle	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	17110340	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

exocyst complex component 4

SEC8-like 1	augmenter of liver regeneration (ALR) pseudogene
exocyst complex component Sec8	rSec8
secretory protein SEC8

Exoc4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Exoc4	Q62824	WWC1	Homo sapiens	Q8IX03-1	Anti Bait CoIP	19885391
Cross	Exoc4	Q62824	WWC1	Homo sapiens	Q8IX03-1	Anti Tag CoIP	19885391
Intra	Exoc4	Q62824	Prkci	Rattus norvegicus	F1M7Y5	Anti Bait CoIP	19885391

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04590	EXOC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Exoc4	NCBI	NCBI:60412

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