Foxn4 - forkhead box N4 Gene

Mus musculus

Gene ID: 116810 | Gene type: protein coding

About Foxn4

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in neural retina development; positive regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron fate commitment. Acts upstream of or within neuron fate commitment. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; metanephros; and respiratory system. Orthologous to human FOXN4 (forkhead box N4). [provided by Alliance of Genome Resources, Apr 2022]

Foxn4 Products(1)

mRNA	Protein	Name
NM_148935.2	NP_683737.2	forkhead box protein N4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23652001	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22323600	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22323600	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	15363391	MGI
involved in amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	15363391	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16020526	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23652001	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22323600	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	15363391	MGI
involved in ventral spinal cord interneuron differentiation	IMP IMP: Inferred from mutant phenotype	20844123	MGI
involved in ventral spinal cord interneuron fate commitment	IMP IMP: Inferred from mutant phenotype	16020526	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22323600	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein N4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05068	FOXN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxn4	NCBI	NCBI:121643

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