Foxn4 - forkhead box N4 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 116810

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in neural retina development; positive regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron fate commitment. Acts upstream of or within neuron fate commitment. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; metanephros; and respiratory system. Orthologous to human FOXN4 (forkhead box N4). [provided by Alliance of Genome Resources, Apr 2022]

Foxn4 Products (1)

mRNA Protein Name
NM_148935.2 NP_683737.2 forkhead box protein N4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23652001 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22323600 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22323600 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amacrine cell differentiation IMP
IMP: Inferred from mutant phenotype
15363391 MGI
involved in amacrine cell differentiation IMP
IMP: Inferred from mutant phenotype
15363391 MGI
acts upstream of or within neuron fate commitment IGI
IGI: Inferred from genetic interaction
16020526 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23652001 MGI
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22323600 MGI
involved in retina layer formation IMP
IMP: Inferred from mutant phenotype
15363391 MGI
involved in ventral spinal cord interneuron differentiation IMP
IMP: Inferred from mutant phenotype
20844123 MGI
involved in ventral spinal cord interneuron fate commitment IMP
IMP: Inferred from mutant phenotype
16020526 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22323600 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein N4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05068 FOXN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxn4 NCBI NCBI:121643