Alox5ap - arachidonate 5-lipoxygenase activating protein Gene

Also Known as Flap

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11690

About Alox5ap

Chromosome 5: 149,201,577-149,224,963 forward strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 10 phenotypes. Broad expression in liver E18 (RPKM 51.8), lung adult (RPKM 33.9) and 22 other tissues.

Summary

Predicted to enable several functions, including arachidonic acid binding activity; Glutathione Peroxidase activity; and glutathione transferase activity. Predicted to contribute to arachidonate 5-lipoxygenase activity. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in nucleus. Is expressed in hemolymphoid system; liver; and vertebra. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Alox5ap Products (2)

mRNA Protein Name
NM_009663.2 NP_033793.1 arachidonate 5-lipoxygenase-activating protein isoform 1 precursor
NM_001308462.1 NP_001295391.1 arachidonate 5-lipoxygenase-activating protein isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19075240 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
19075240 MGI
acts upstream of or within leukotriene biosynthetic process IMP
IMP: Inferred from mutant phenotype
9091580 MGI
acts upstream of or within leukotriene production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
9091580 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19075240 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox5ap Protein Structure

MAPEG

MAPEG: pfam01124 (8 - 127)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

arachidonate 5-lipoxygenase-activating protein

  • MK-886-binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox5ap NCBI NCBI:241