2. Gene
  3. Dph1 - diphthamide biosynthesis 1 Gene

Dph1 - diphthamide biosynthesis 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ovca1; Dph2l1; 2310011M22Rik; 4930488F09Rik

Gene ID: 116905 | Gene type: protein coding

About Dph1

Summary

Predicted to enable transferase activity. Acts upstream of or within cell population proliferation. Predicted to be located in cell junction and nucleoplasm. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; liver; and lung. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Apr 2022]

Dph1 Products(1)

mRNA Protein Name
NM_144491.2 NP_652762.2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity IGI
IGI: Inferred from genetic interaction
15485916 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15485916 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
14744934 MGI
involved in protein histidyl modification to diphthamide IMP
IMP: Inferred from mutant phenotype
24895408 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

DPH1 homolog

DPH2-like 1

S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1

diphthamide biosynthesis protein 1

diphthamide biosynthesis protein 2 homolog-like 1

diphtheria toxin resistance protein 1

diptheria toxin resistance p

Dph1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Dph1 Q5NCQ5 Dph2 Mus musculus Q9CR25
Anti Tag CoIP
15485916
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03952 DPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dph1 NCBI NCBI:1801