Rab8a - RAB8A, member RAS oncogene family Gene

Rattus norvegicus

Also known as Mel; Rab8

Gene ID: 117103 | Gene type: protein coding

About Rab8a

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to Insulin stimulus; neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse. Colocalizes with Golgi apparatus. Orthologous to human RAB8A (RAB8A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab8a Products(1)

mRNA	Protein	Name
NM_053998.2	NP_446450.2	ras-related protein Rab-8A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	21856246	RGD
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	21041651	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IDA IDA: Inferred from direct assay	15297461	RGD
involved in neurotransmitter receptor transport to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	15297461	RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	18045925	RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	18045925	RGD
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	21041651	RGD
involved in regulation of long-term neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	15297461	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18045925	RGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	18701652	RGD
involved in regulation of protein transport	IDA IDA: Inferred from direct assay	15297461	RGD
involved in regulation of protein transport	IMP IMP: Inferred from mutant phenotype	8408204	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	15297461	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	15297461	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15837803	RGD
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15837803	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8408204	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15297461	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15297461	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8408204	RGD
is active in synapse	EXP EXP: Inferred from Experiment	24876496	RGD
is active in synapse	IDA IDA: Inferred from direct assay	24876496	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-8A

mel transforming oncogene (derived from cell line NK14)- RAB8 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136197	StRIP16	Inhibitor	/	Unkown
HY-RS22764	Rab8a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174420	RN277	Inhibitor	/	Unkown
HY-RS11578	RAB8A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab8a	NCBI	NCBI:4218

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