Rab8a - RAB8A, member RAS oncogene family Gene

Also Known as Mel; Rab8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117103

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to Insulin stimulus; neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse. Colocalizes with Golgi apparatus. Orthologous to human RAB8A (RAB8A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab8a Products (1)

mRNA Protein Name
NM_053998.2 NP_446450.2 ras-related protein Rab-8A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12700184 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12700184 RGD
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
21856246 RGD
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
21041651 RGD
involved in neurotransmitter receptor transport to postsynaptic membrane IDA
IDA: Inferred from direct assay
15297461 RGD
involved in neurotransmitter receptor transport to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
15297461 RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
IDA: Inferred from direct assay
18045925 RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
18045925 RGD
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
21041651 RGD
involved in regulation of long-term neuronal synaptic plasticity IDA
IDA: Inferred from direct assay
15297461 RGD
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
18045925 RGD
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
18701652 RGD
involved in regulation of protein transport IDA
IDA: Inferred from direct assay
15297461 RGD
involved in regulation of protein transport IMP
IMP: Inferred from mutant phenotype
8408204 RGD
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
15297461 RGD
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
15297461 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15837803 RGD
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15837803 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8408204 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15297461 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15297461 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8408204 RGD
is active in synapse EXP
EXP: Inferred from Experiment
24876496 RGD
is active in synapse IDA
IDA: Inferred from direct assay
24876496 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rab-8A

  • mel transforming oncogene (derived from cell line NK14)- RAB8 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136197 StRIP16 Inhibitor 95.38% Unkown
HY-174420 RN277 Inhibitor / Unkown
HY-RS11578 RAB8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22764 Rab8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rab8a NCBI NCBI:4218