Epn1 - Epsin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117277

Summary

Enables clathrin adaptor activity and transmembrane transporter binding activity. Involved in endocytosis; membrane fission; and positive regulation of clathrin coat assembly. Located in cytosol; nucleus; and presynapse. Is extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of postsynaptic membrane; and extrinsic component of presynaptic membrane. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of middle cerebral artery infarction. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Apr 2022]

Epn1 Products (1)

mRNA Protein Name
NM_057136.2 NP_476477.1 epsin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables clathrin adaptor activity IMP
IMP: Inferred from mutant phenotype
11756460 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16537494 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
10559257 RGD
Biological Process GO Annotation Evidence References Source
involved in clathrin coat assembly IDA
IDA: Inferred from direct assay
11756460 RGD
involved in endocytosis IDA
IDA: Inferred from direct assay
12353027 RGD
involved in membrane fission IDA
IDA: Inferred from direct assay
25799353 RGD
involved in positive regulation of clathrin coat assembly IMP
IMP: Inferred from mutant phenotype
11756460 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
16320245 RGD
located in cytosol IDA
IDA: Inferred from direct assay
11756460 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
16320245 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
16320245 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
16320245 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
16320245 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epsin-1

  • EPS-15-interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04443 EPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epn1 NCBI NCBI:29924