Csrp3 - cysteine and glycine rich protein 3 Gene

Also Known as MLP; CRP3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117505

Summary

Enables MRF binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in blood vessel remodeling. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of myotube differentiation. Located in Z disc and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Csrp3 Products (1)

mRNA Protein Name
NM_057144.2 NP_476485.2 cysteine and glycine-rich protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MRF binding IDA
IDA: Inferred from direct assay
9234731 RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
9234731 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9234731 RGD
Biological Process GO Annotation Evidence References Source
involved in blood vessel remodeling IEP
IEP: Inferred from expression pattern
16519896 RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9234731 RGD
acts upstream of or within positive regulation of myotube differentiation IDA
IDA: Inferred from direct assay
9234731 RGD
acts upstream of or within positive regulation of myotube differentiation IGI
IGI: Inferred from genetic interaction
9234731 RGD
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
12507422 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
9234731 RGD
located in nucleus IDA
IDA: Inferred from direct assay
9234731 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cysteine and glycine-rich protein 3

  • LIM domain protein, cardiac

  • cysteine and glycine rich protein 3 N-terminal nuclear localization sequence

  • cysteine and glycine rich protein 3 c-terminal HA-tagged

  • cysteine and glycine rich protein 3 lacking the LIM1-domain

  • cysteine and glycine-rich pro

Csrp3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Csrp3 P50463 Myod1 Mus musculus P10085
Pull Down
9234731
Cross
Csrp3 P50463 Myod1 Mus musculus P10085
Anti Bait CoIP
9234731
Cross
Csrp3 P50463 Myod1 Mus musculus P10085
Pull Down
10751147
Cross
Csrp3 P50463 SPTB Homo sapiens P11277
Y2H
10751147
Cross
Csrp3 P50463 SPTB Homo sapiens P11277
Pull Down
10751147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03260 CSRP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csrp3 NCBI NCBI:8048