Csrp3 - cysteine and glycine rich protein 3 Gene

Rattus norvegicus

Also known as MLP; CRP3

Gene ID: 117505 | Gene type: protein coding

About Csrp3

Summary

Enables MRF binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in blood vessel remodeling. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of myotube differentiation. Located in Z disc and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Csrp3 Products(1)

mRNA	Protein	Name
NM_057144.2	NP_476485.2	cysteine and glycine-rich protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MRF binding	IDA IDA: Inferred from direct assay	9234731	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9234731	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9234731	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel remodeling	IEP IEP: Inferred from expression pattern	16519896	RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9234731	RGD
acts upstream of or within positive regulation of myotube differentiation	IDA IDA: Inferred from direct assay	9234731	RGD
acts upstream of or within positive regulation of myotube differentiation	IGI IGI: Inferred from genetic interaction	9234731	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	12507422	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	9234731	RGD
located in nucleus	IDA IDA: Inferred from direct assay	9234731	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cysteine and glycine-rich protein 3

LIM domain protein, cardiac	cysteine and glycine rich protein 3 N-terminal nuclear localization sequence
cysteine and glycine rich protein 3 c-terminal HA-tagged	cysteine and glycine rich protein 3 lacking the LIM1-domain
cysteine and glycine-rich pro

Csrp3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Csrp3	P50463	Myod1	Mus musculus	P10085	Pull Down	9234731
Cross	Csrp3	P50463	Myod1	Mus musculus	P10085	Anti Bait CoIP	9234731
Cross	Csrp3	P50463	Myod1	Mus musculus	P10085	Pull Down	10751147
Cross	Csrp3	P50463	SPTB	Homo sapiens	P11277	Y2H	10751147
Cross	Csrp3	P50463	SPTB	Homo sapiens	P11277	Pull Down	10751147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03260	CSRP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csrp3	NCBI	NCBI:8048

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