St8sia2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Gene

Rattus norvegicus

Also known as STX; Siat8b; SIAT8-B

Gene ID: 117523 | Gene type: protein coding

About St8sia2

Summary

Enables Sialyltransferase activity. Involved in several processes, including neuron projection extension; positive regulation of synapse assembly; and response to cocaine. Located in perinuclear region of cytoplasm and plasma membrane. Orthologous to human ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

St8sia2 Products(1)

mRNA	Protein	Name
NM_057156.2	NP_476497.1	alpha-2,8-sialyltransferase 8B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sialyltransferase activity	IMP IMP: Inferred from mutant phenotype	16887122	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	8703013	RGD
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	16887122	RGD
involved in positive regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	14635225	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	16887122	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	21536109	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14635225	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-2,8-sialyltransferase 8B

ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2	ST8Sia II
ST8SiaII	sialyltransferase 8 (alpha-2, 8-sialyltransferase) B
sialyltransferase 8 (alpha-2, 8-sialytransferase) B	sialyltransferase 8B
sialyltransferase St8Sia II	sialyltransfera

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13857	ST8SIA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	St8sia2	NCBI	NCBI:8128

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