ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Gene

Also Known as STX; SIAT8B; SIAT8-B; HsT19690; ST8SiaII; ST8SIA-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8128

About ST8SIA2

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:92,393,881-92,468,728 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 5 paralogues. Biased expression in heart (RPKM 1.6), brain (RPKM 0.9) and 4 other tissues.

Summary

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of Glycosyltransferase family 29. [provided by RefSeq, Jul 2008]

ST8SIA2 Products (2)

mRNA Protein Name
NM_001330416.2 NP_001317345.1 alpha-2,8-sialyltransferase 8B isoform 2 precursor
NM_006011.4 NP_006002.1 alpha-2,8-sialyltransferase 8B isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
IDA: Inferred from direct assay
9774483 GOA
Biological Process GO Annotation Evidence References Source
involved in N-glycan processing IDA
IDA: Inferred from direct assay
10766765 GOA
involved in ganglioside biosynthetic process IDA
IDA: Inferred from direct assay
10766765 GOA
involved in oligosaccharide metabolic process IDA
IDA: Inferred from direct assay
10766765 GOA
involved in protein glycosylation IDA
IDA: Inferred from direct assay
10766765 GOA
involved in sialylation IDA
IDA: Inferred from direct assay
7559389 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
9852130 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
11744634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST8SIA2 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (109 - 369)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

alpha-2,8-sialyltransferase 8B

  • ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2

Related Diseases

Diseases Alias
Acute Diarrhea
Shigellosis

  • Dysentery, Bacillary

  • Bacillary Dysentery

  • Shigella Boydii Infectious Disease

  • Shigella Flexneri Infectious Disease

  • Shigella Gastroenteritis

  • Shigella Sonnei Infectious Disease

  • Shigella Infections
Dysentery

  • Infectious Diarrhea
Osteogenesis Imperfecta, Type Xx

  • OI20

  • Osteogenesis Imperfecta Type 20

  • Osteogenesis Imperfecta, Type 20

  • Osteogenesis Imperfecta Type Xx

  • Osteogenesis Imperfecta 20
Visual Cortex Disease

  • Visual Cortex Dysfunction

  • Visual Cortex Disorder

  • Visual Cortical Disorder

  • Disease Of Visual Cortex
Visual Pathway Disease

  • Disorder Of Visual Pathways
Campylobacteriosis

  • Campylobacter Infections

  • Campylobacter Infection

  • Enteric Campylobacteriosis
Cortical Blindness

  • Blindness, Cortical
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Hemolytic Uremic Syndrome, Atypical 1

  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical
Blood Platelet Disease

  • Platelet Disorder

  • Blood Platelet Disorders

  • Thrombocytopathy

  • Platelet Dysfunction

  • Platelet Disorders

  • Qualitative Platelet Deficiency
Hemolytic Anemia

  • Anemia, Hemolytic

  • Anemia Hemolytic

  • Anaemia Due To Other Disorders Of Glutathione Metabolism

  • Chronic Non Spherocytic Anaemia

  • G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

  • Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

  • Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

  • Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

  • Favism Anaemia

  • Haemolytic Anaemia Due Tog6pd Deficiency

  • Favism

  • Pentose Phosphate Pathway Disorder Anaemia

  • Anaemia Due To Pentose Phosphate Pathway Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13857 ST8SIA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ST8SIA2 VGNC VGNC:46865
Macaca mulatta ST8SIA2 VGNC VGNC:77831
Felis catus ST8SIA2 VGNC VGNC:65736
Mus musculus ST8SIA2 MGD MGI:106020
Rattus norvegicus ST8SIA2 RGD RGD:621843
Bos taurus ST8SIA2 VGNC VGNC:35344
Others ST8SIA2 NCBI