Phox2a - paired-like homeobox 2a Gene

Also Known as Arix; Pmx2; Px2a; Phox2; Pmx2a

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11859

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in oculomotor nerve formation and trochlear nerve formation. Acts upstream of or within nervous system development; regulation of respiratory gaseous exchange; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; epibranchial placode; genitourinary system; and nervous system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 2. Orthologous to human PHOX2A (paired like homeobox 2A). [provided by Alliance of Genome Resources, Apr 2022]

Phox2a Products (1)

mRNA	Protein	Name
NM_008887.2	NP_032913.1	paired mesoderm homeobox protein 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	32094113	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	32094113	MGI
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	32094113	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within locus ceruleus development	IMP IMP: Inferred from mutant phenotype	9115735	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	21752929	MGI
acts upstream of or within noradrenergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	21068058	MGI
involved in oculomotor nerve formation	IMP IMP: Inferred from mutant phenotype	9374403	MGI
acts upstream of or within parasympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	9115735	MGI
acts upstream of or within regulation of respiratory gaseous exchange	IMP IMP: Inferred from mutant phenotype	17218061	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	32094113	MGI
acts upstream of or within somatic motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	16319924	MGI
acts upstream of or within sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	9115735	MGI
involved in trochlear nerve formation	IMP IMP: Inferred from mutant phenotype	9374403	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12023301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
paired mesoderm homeobox protein 2A	PHOX2A homeodomain protein aristaless homeobox gene homolog aristaless homeobox protein homolog paired mesoderm homeobox 2a

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10451	PHOX2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Phox2a	NCBI	NCBI:401