Arnt2 - aryl hydrocarbon receptor nuclear translocator 2 Gene

Mus musculus

Also known as Hif-2b; bHLHe1; mKIAA0307

Gene ID: 11864 | Gene type: protein coding

About Arnt2

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Aryl Hydrocarbon Receptor binding activity; and protein heterodimerization activity. Involved in central nervous system development and positive regulation of transcription, DNA-templated. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARNT2 (Aryl Hydrocarbon Receptor nuclear translocator 2). [provided by Alliance of Genome Resources, Apr 2022]

Arnt2 Products(7)

mRNA	Protein	Name
NM_001411920.1	NP_001398849.1	aryl hydrocarbon receptor nuclear translocator 2 isoform b
NM_001411921.1	NP_001398850.1	aryl hydrocarbon receptor nuclear translocator 2 isoform c
NM_001411922.1	NP_001398851.1	aryl hydrocarbon receptor nuclear translocator 2 isoform c
NM_001411923.1	NP_001398852.1	aryl hydrocarbon receptor nuclear translocator 2 isoform c
NM_001411924.1	NP_001398853.1	aryl hydrocarbon receptor nuclear translocator 2 isoform d
NM_001411925.1	NP_001398854.1	aryl hydrocarbon receptor nuclear translocator 2 isoform e
NM_007488.4	NP_031514.3	aryl hydrocarbon receptor nuclear translocator 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8657146	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8657146	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8657146	MGI
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	8657146	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27782878	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	27782878	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8927054	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in central nervous system development	IMP IMP: Inferred from mutant phenotype	11318878	MGI
involved in in utero embryonic development	IEP IEP: Inferred from expression pattern	12502753	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8657146	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701734	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8657146	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14701734	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14701734	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor nuclear translocator 2

ARNT protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10996	KHS101		/	Unkown
HY-RS01012	ARNT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arnt2	NCBI	NCBI:9915

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