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Arx - aristaless related homeobox Gene

Also Known as Arx1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11878

Summary

This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Arx Products (2)

mRNA	Protein	Name
NM_001305940.1	NP_001292869.1	homeobox protein ARX
NM_007492.4	NP_031518.2	homeobox protein ARX

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15930104	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15930104	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	21966449	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15677725	MGI
acts upstream of or within cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	15677725	MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration	IMP IMP: Inferred from mutant phenotype	17460091	MGI
acts upstream of or within cerebral cortex tangential migration	IMP IMP: Inferred from mutant phenotype	17460091	MGI
acts upstream of or within embryonic olfactory bulb interneuron precursor migration	IMP IMP: Inferred from mutant phenotype	15677725	MGI
acts upstream of or within epithelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	22387004	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	12379852	MGI
acts upstream of or within globus pallidus development	IMP IMP: Inferred from mutant phenotype	17460091	MGI
acts upstream of or within interneuron migration	IMP IMP: Inferred from mutant phenotype	12379852	MGI
acts upstream of or within lipid digestion	IMP IMP: Inferred from mutant phenotype	22387004	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15930104	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	12379852	MGI
acts upstream of or within olfactory bulb development	IMP IMP: Inferred from mutant phenotype	15677725	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	15677725	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23246292	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	15677725	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31691806	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12379852	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein ARX

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132987	Avibactam tomilopil	Inhibitor	98.57%	Phase 1

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990697	Anvatabart	Inhibitor	98.15%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01051	ARX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15320	UBA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19646	Uba2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991204	Anti-PSMA Antibody	Inhibitor	96.31%	Unkown
HY-P991930	ARX305 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arx	NCBI	NCBI:170302