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Atoh1 - atonal bHLH transcription factor 1 Gene

Also Known as Hath1; Math1; MATH-1; bHLHa14

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11921

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and positive regulation of inner ear auditory receptor cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skin. Orthologous to human ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Atoh1 Products (1)

mRNA	Protein	Name
NM_007500.5	NP_031526.1	transcription factor Atoh1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14757642	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17826772	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17826772	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	15788459	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14757642	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16679559	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25535395	MGI
acts upstream of or within auditory receptor cell fate determination	IDA IDA: Inferred from direct assay	16407553	MGI
acts upstream of or within auditory receptor cell fate specification	IMP IMP: Inferred from mutant phenotype	10364557	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	16145671	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12223565	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	15543141	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	16325379	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11973280	MGI
acts upstream of inner ear auditory receptor cell differentiation	IDA IDA: Inferred from direct assay	19154718	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IDA IDA: Inferred from direct assay	15543141	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	11973280	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	21146598	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15543141	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11973280	MGI
involved in negative regulation of gliogenesis	IGI IGI: Inferred from genetic interaction	32665354	MGI
acts upstream of or within neuroblast migration	IMP IMP: Inferred from mutant phenotype	16202707	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	14999071	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	16202707	MGI
acts upstream of or within positive regulation of inner ear auditory receptor cell differentiation	IDA IDA: Inferred from direct assay	11023859	MGI
acts upstream of or within positive regulation of inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	21146598	MGI
involved in positive regulation of inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	12208538	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10648228	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16679559	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17826772	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15788459	MGI
acts upstream of or within regulation of neuron differentiation	IDA IDA: Inferred from direct assay	14757642	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15788459	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10648228	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor Atoh1	atonal homolog 1 helix-loop-helix protein mATH-1 protein atonal homolog 1

Atoh1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Atoh1	P48985	Tcf4	Mus musculus	Q91YV0	Anti Tag CoIP	17878293

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01165	ATOH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atoh1	NCBI	NCBI:474