Atp2b2 - ATPase, Ca++ transporting, plasma membrane 2 Gene

Mus musculus

Also known as Tmy; dfw; jog; wms; wri; PMCA2; D6Abb2e; Gena300

Gene ID: 11941 | Gene type: protein coding

About Atp2b2

Summary

Enables calcium-dependent ATPase activity. Involved in cochlea development and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including animal organ development; cGMP metabolic process; and detection of mechanical stimulus involved in sensory perception of sound. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b2 Products(12)

mRNA	Protein	Name
NM_001036684.4	NP_001031761.1	plasma membrane calcium-transporting ATPase 2 isoform 1
NM_001347365.2	NP_001334294.1	plasma membrane calcium-transporting ATPase 2 isoform 2
NM_001409523.1	NP_001396452.1	plasma membrane calcium-transporting ATPase 2 isoform 2
NM_001409524.1	NP_001396453.1	plasma membrane calcium-transporting ATPase 2 isoform 3
NM_001409526.1	NP_001396455.1	plasma membrane calcium-transporting ATPase 2 isoform 1
NM_001409529.1	NP_001396458.1	plasma membrane calcium-transporting ATPase 2 isoform 1
NM_001409533.1	NP_001396462.1	plasma membrane calcium-transporting ATPase 2 isoform 4
NM_001409534.1	NP_001396463.1	plasma membrane calcium-transporting ATPase 2 isoform 5
NM_001409535.1	NP_001396464.1	plasma membrane calcium-transporting ATPase 2 isoform 6
NM_001409536.1	NP_001396465.1	plasma membrane calcium-transporting ATPase 2 isoform 7
NM_001409537.1	NP_001396466.1	plasma membrane calcium-transporting ATPase 2 isoform 7
NM_009723.7	NP_033853.1	plasma membrane calcium-transporting ATPase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent ATPase activity	IMP IMP: Inferred from mutant phenotype	17823248	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	11875276	MGI
acts upstream of or within cGMP metabolic process	IMP IMP: Inferred from mutant phenotype	3038581	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	15302868	MGI
involved in calcium ion transport	IMP IMP: Inferred from mutant phenotype	17234811	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10441500	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	9668038	MGI
acts upstream of or within cerebellar Purkinje cell layer morphogenesis	IMP IMP: Inferred from mutant phenotype	17409239	MGI
acts upstream of or within cerebellar granule cell differentiation	IMP IMP: Inferred from mutant phenotype	9668038	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	16880690	MGI
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	9668038	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16529873	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17234811	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	11875276	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	9668038	MGI
acts upstream of or within inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	11875276	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	11985881	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	15302868	MGI
acts upstream of or within locomotion	IMP IMP: Inferred from mutant phenotype	16880690	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	2765934	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	9668038	MGI
acts upstream of or within neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	11985881	MGI
acts upstream of or within organelle organization	IMP IMP: Inferred from mutant phenotype	11875276	MGI
acts upstream of or within otolith mineralization	IMP IMP: Inferred from mutant phenotype	9668038	MGI
acts upstream of or within positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	17823248	MGI
acts upstream of or within regulation of cell size	IMP IMP: Inferred from mutant phenotype	11875276	MGI
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	17234811	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17409239	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	9325047	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	9325047	MGI
acts upstream of or within serotonin metabolic process	IMP IMP: Inferred from mutant phenotype	2765934	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	7683393	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17823248	MGI
located in cilium	IDA IDA: Inferred from direct assay	10441500	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17234811	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19233278	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	10441500	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	10441500	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	19233278	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17234811	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	19233278	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plasma membrane calcium-transporting ATPase 2

deaf waddler	plasma membrane calcium ATPase
plasma membrane calcium pump	wriggle

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01195	ATP2B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01197	ATP2B4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp2b2	NCBI	NCBI:491

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