Atp2b2 - ATPase, Ca++ transporting, plasma membrane 2 Gene

Also Known as Tmy; dfw; jog; wms; wri; PMCA2; D6Abb2e; Gena300

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11941

Summary

Enables calcium-dependent ATPase activity. Involved in cochlea development and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including animal organ development; cGMP metabolic process; and detection of mechanical stimulus involved in sensory perception of sound. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b2 Products (12)

mRNA Protein Name
NM_001036684.4 NP_001031761.1 plasma membrane calcium-transporting ATPase 2 isoform 1
NM_001347365.2 NP_001334294.1 plasma membrane calcium-transporting ATPase 2 isoform 2
NM_001409523.1 NP_001396452.1 plasma membrane calcium-transporting ATPase 2 isoform 2
NM_001409524.1 NP_001396453.1 plasma membrane calcium-transporting ATPase 2 isoform 3
NM_001409526.1 NP_001396455.1 plasma membrane calcium-transporting ATPase 2 isoform 1
NM_001409529.1 NP_001396458.1 plasma membrane calcium-transporting ATPase 2 isoform 1
NM_001409533.1 NP_001396462.1 plasma membrane calcium-transporting ATPase 2 isoform 4
NM_001409534.1 NP_001396463.1 plasma membrane calcium-transporting ATPase 2 isoform 5
NM_001409535.1 NP_001396464.1 plasma membrane calcium-transporting ATPase 2 isoform 6
NM_001409536.1 NP_001396465.1 plasma membrane calcium-transporting ATPase 2 isoform 7
NM_001409537.1 NP_001396466.1 plasma membrane calcium-transporting ATPase 2 isoform 7
NM_009723.7 NP_033853.1 plasma membrane calcium-transporting ATPase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent ATPase activity IMP
IMP: Inferred from mutant phenotype
17823248 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
11875276 MGI
acts upstream of or within cGMP metabolic process IMP
IMP: Inferred from mutant phenotype
3038581 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
15302868 MGI
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
17234811 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
10441500 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
9668038 MGI
acts upstream of or within cerebellar Purkinje cell layer morphogenesis IMP
IMP: Inferred from mutant phenotype
17409239 MGI
acts upstream of or within cerebellar granule cell differentiation IMP
IMP: Inferred from mutant phenotype
9668038 MGI
acts upstream of or within cerebellum development IMP
IMP: Inferred from mutant phenotype
16880690 MGI
involved in cochlea development IMP
IMP: Inferred from mutant phenotype
9668038 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
16529873 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17234811 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
11875276 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
9668038 MGI
acts upstream of or within inner ear receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
11875276 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
11985881 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
15302868 MGI
acts upstream of or within locomotion IMP
IMP: Inferred from mutant phenotype
16880690 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
2765934 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
9668038 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
11985881 MGI
acts upstream of or within organelle organization IMP
IMP: Inferred from mutant phenotype
11875276 MGI
acts upstream of or within otolith mineralization IMP
IMP: Inferred from mutant phenotype
9668038 MGI
acts upstream of or within positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
17823248 MGI
acts upstream of or within regulation of cell size IMP
IMP: Inferred from mutant phenotype
11875276 MGI
involved in regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
17234811 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17409239 MGI
acts upstream of or within sensory perception of sound IGI
IGI: Inferred from genetic interaction
9325047 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
9325047 MGI
acts upstream of or within serotonin metabolic process IMP
IMP: Inferred from mutant phenotype
2765934 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
7683393 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17823248 MGI
located in cilium IDA
IDA: Inferred from direct assay
10441500 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17234811 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19233278 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
10441500 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
10441500 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
19233278 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17234811 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19233278 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma membrane calcium-transporting ATPase 2

  • deaf waddler

  • plasma membrane calcium ATPase

  • plasma membrane calcium pump

  • wriggle

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01195 ATP2B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01197 ATP2B4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2b2 NCBI NCBI:491