Bag1 - BCL2-associated athanogene 1 Gene

Also Known as BAG-1; Rap46

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12017

Summary

The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to Apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]

Bag1 Products (2)

mRNA Protein Name
NM_001171739.1 NP_001165210.1 BAG family molecular chaperone regulator 1 isoform 1S
NM_009736.3 NP_033866.4 BAG family molecular chaperone regulator 1 isoform 1L

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7834747 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16116448 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
7834747 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16116448 MGI
acts upstream of or within negative regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16116448 MGI
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16116448 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
11965493 MGI
acts upstream of or within protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
16116448 MGI
acts upstream of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16116448 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11965493 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9396724 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BAG family molecular chaperone regulator 1

  • Bcl-2-binding protein

  • bcl-2-associated athanogene 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124611 JG-231 98.47% Unkown
HY-124811 IRES-C11 Inhibitor 98.01% Unkown
HY-RS01342 BAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bag1 NCBI NCBI:573