Bop1 - block of proliferation 1 Gene

Also Known as Erb1p; Kiaa0124; mKIAA0124

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12181

Summary

Enables ribonucleoprotein complex binding activity. Involved in cell population proliferation and cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Acts upstream of or within rRNA processing and ribosomal large subunit biogenesis. Located in nucleolus. Is expressed in several structures, including female reproductive system and urinary system. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]

Bop1 Products (1)

mRNA Protein Name
NM_013481.2 NP_038509.1 ribosome biogenesis protein BOP1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15225545 MGI
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
10891491 MGI
Biological Process GO Annotation Evidence References Source
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
17353269 MGI
involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: Inferred from mutant phenotype
17353269 MGI
involved in maturation of 5.8S rRNA IMP
IMP: Inferred from mutant phenotype
10891491 MGI
acts upstream of or within rRNA processing IGI
IGI: Inferred from genetic interaction
15225545 MGI
acts upstream of or within rRNA processing IMP
IMP: Inferred from mutant phenotype
10891491 MGI
acts upstream of or within ribosomal large subunit biogenesis IMP
IMP: Inferred from mutant phenotype
10891491 MGI
involved in ribosomal large subunit biogenesis IMP
IMP: Inferred from mutant phenotype
10891491 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
17353269 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribosome biogenesis protein BOP1

  • block of proliferation 1 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01576 BOP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bop1 NCBI NCBI:23246