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BOP1 - BOP1 ribosomal biogenesis factor Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23246

About BOP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,262,045-144,291,438 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 182 orthologues. Ubiquitous expression in testis (RPKM 10.2), appendix (RPKM 9.2) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Apr 2022]

BOP1 Products (1)

mRNA	Protein	Name
NM_015201.5	NP_056016.1	ribosome biogenesis protein BOP1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16043514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP IMP: Inferred from mutant phenotype	17353269	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	16043514	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit assembly	IMP IMP: Inferred from mutant phenotype	24120868	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PeBoW complex	IDA IDA: Inferred from direct assay	16043514	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BOP1 Protein Structure

BOP1NT

WD40

0
200
400
600
746 a.a.

Protein Preferred Names	Protein Names
ribosome biogenesis protein BOP1	block of proliferation 1

BOP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BOP1	Q14137	PES1	Homo sapiens	O00541	Comig Non-Denat Gel	16043514
Intra	BOP1	Q14137	PES1	Homo sapiens	O00541	Anti Bait CoIP	16043514
Intra	BOP1	Q14137	WDR12	Homo sapiens	Q9GZL7	Anti Bait CoIP	16043514
Intra	BOP1	Q14137	WDR12	Homo sapiens	Q9GZL7	Comig Non-Denat Gel	16043514

Cross: Cross-species interaction Intra: Intraspecies interaction

BOP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89786	BOP1 Antibody (YA9130)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01576	BOP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BOP1	VGNC	VGNC:70315
Felis catus	BOP1	VGNC	VGNC:60149
Canis familiaris	BOP1	VGNC	VGNC:38498
Mus musculus	BOP1	MGD	MGI:1334460
Bos taurus	BOP1	VGNC	VGNC:26540
Rattus norvegicus	BOP1	RGD	RGD:1310589
Others	BOP1	NCBI