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PES1 - pescadillo ribosomal biogenesis factor 1 Gene

Also Known as PES; NOP7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23481

About PES1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,576,625-30,607,013 (from NCBI)

This gene has 13 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 9.0), ovary (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a nuclear protein that contains a breast Cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast Cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

PES1 Products (4)

mRNA	Protein	Name
NM_001243225.2	NP_001230154.1	pescadillo homolog isoform 2
NM_001282327.1	NP_001269256.1	pescadillo homolog isoform 3
NM_001282328.1	NP_001269257.1	pescadillo homolog isoform 3
NM_014303.4	NP_055118.1	pescadillo homolog isoform 1

PES1 Protein Structure

Pescadillo_N

BRCT

0
100
200
300
400
500
588 a.a.

Protein Preferred Names	Protein Names
pescadillo homolog	pescadillo homolog 1, containing BRCT domain

PES1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PES1	O00541	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	28514442
Intra	PES1	O00541	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	35271311
Intra	PES1	O00541	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	33961781
Intra	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Anti Tag CoIP	33961781
Intra	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Anti Tag CoIP	28514442
Intra	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Anti Tag CoIP	35271311
Intra	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Crosslink	30021884
Intra	PES1	O00541	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PES1	O00541	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PES1	O00541	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PES1	O00541	FOXM1	Homo sapiens	Q08050	Pull Down	25609649
Intra	PES1	O00541	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PES1	O00541	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PES1	O00541	ATXN1	Homo sapiens	P54253	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0304A	Dapoxetine hydrochloride	Inhibitor	99.96%	Unkown
HY-B0304	Dapoxetine	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120991	1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE		98.0%	Unkown
HY-157697	1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE		≥99.0%	Unkown
HY-143671S	1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE-d11		99.0%	Unkown
HY-P1695	Cinnamycin	Inhibitor	98.4%	Unkown
HY-141617S	1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PE		/	Unkown
HY-165116	1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE		/	Unkown
HY-170021	Dapoxetine-d7	Inhibitor	/	Unkown
HY-170459	18:1-12:0 Biotin PE		/	Unkown
HY-P5809	Pe1b	Inhibitor	/	Unkown
HY-RS10336	PES1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11392	PTGS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W583868S	1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62		/	Unkown
HY-145473S	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11		/	Unkown
HY-158750	1-1(Z)-Octadecenyl-2-adrenoyl-sn-glycero-3-pe		/	Unkown
HY-158947	1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE		/	Unkown
HY-158947S	1-1(Z)-Hexadecenyl-2-Palmitoyl-d9-sn-glycero-3-PE		/	Unkown
HY-167894	DA-8031	Inhibitor	/	Unkown
HY-W290532	(Rac)-Dapoxetine hydrochloride	Inhibitor	99.49%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PES1	VGNC	VGNC:68788
Canis familiaris	PES1	VGNC	VGNC:44425
Macaca mulatta	PES1	VGNC	VGNC:75944
Bos taurus	PES1	VGNC	VGNC:32750
Mus musculus	PES1	MGD	MGI:1890613
Rattus norvegicus	PES1	RGD	RGD:1559814
Others	PES1	NCBI