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Cat. No.: HY-P5809

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Pe1b

(Synonyms: μ-TrTx-Pe1b)

Pe1b (μ-TrTx-Pe1b) is a selective Na_v1.7 inhibitor with an IC₅₀ of 167 nM.

For research use only. We do not sell to patients.

Formula: C₁₇₅H₂₃₇N₄₇O₄₉S₆
Molecular Weight:3975.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pe1b Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Pe1b (μ-TrTx-Pe1b) is a selective Na_v1.7 inhibitor with an IC₅₀ of 167 nM^[1].

IC₅₀ & Target

IC50: 167 nM (Na_v1.7), 696 nM (Na_v1.6), 3.49 μM (Na_v1.2), ＞10 μM (Na_v1.5)^[1]

All Sodium Channel Isoforms :

Chemical Information

Molecular Weight 3975.43
Formula C₁₇₅H₂₃₇N₄₇O₄₉S₆
Synonyms

μ-TrTx-Pe1b
Sequence

Glu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Lys-Thr-Gly-Asp-Cys-Cys-Glu-His-Leu-Ser-Cys-Ser-Pro-Lys-Trp-His-Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe (Disulfide bridge: Cys2-Cys16,Cys9-Cys21,Cys15-Cys28)
Sequence Shortening

ECRYWLGGCSKTGDCCEHLSCSPKWHWCVWDGTF (Disulfide bridge: Cys2-Cys16,Cys9-Cys21,Cys15-Cys28)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rupasinghe DB, et al. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochem Pharmacol. 2020 Nov;181:114080. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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