WDR12 - WD repeat domain 12 Gene

Also Known as YTM1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55759

About WDR12

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:202,874,261-202,911,673 (from NCBI)

This gene has 9 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 5.2), kidney (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

WDR12 Products (2)

mRNA Protein Name
NM_001371664.1 NP_001358593.1 ribosome biogenesis protein WDR12 isoform 2
NM_018256.4 NP_060726.3 ribosome biogenesis protein WDR12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16043514 GOA
Biological Process GO Annotation Evidence References Source
involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: Inferred from mutant phenotype
16043514 GOA
involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: Inferred from mutant phenotype
16043514 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
16043514 GOA
Cellular Component GO Annotation Evidence References Source
part of PeBoW complex IDA
IDA: Inferred from direct assay
16043514 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16043514 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16043514 GOA
part of preribosome, large subunit precursor IDA
IDA: Inferred from direct assay
17353269 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR12 Protein Structure

NLE

NLE: NLE (NUC135) domain (3 - 70)

WD40

WD40: WD domain, G-beta repeat (100 - 127)

WD40

WD40: WD domain, G-beta repeat (131 - 171)

WD40

WD40: WD domain, G-beta repeat (182 - 217)

WD40

WD40: WD domain, G-beta repeat (248 - 284)

WD40

WD40: WD domain, G-beta repeat (289 - 325)

WD40

WD40: WD domain, G-beta repeat (337 - 371)

WD40

WD40: WD domain, G-beta repeat (378 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

ribosome biogenesis protein WDR12

  • WD repeat-containing protein 12

WDR12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR12 Q9GZL7 BOP1 Homo sapiens Q14137
Anti Tag CoIP
35271311
Intra
WDR12 Q9GZL7 PES1 Homo sapiens O00541
Anti Tag CoIP
35271311
Intra
WDR12 Q9GZL7 PES1 Homo sapiens O00541
Anti Bait CoIP
16043514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15762 WDR12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus WDR12 MGD MGI:1927241
Rattus norvegicus WDR12 RGD RGD:735072
Bos taurus WDR12 VGNC VGNC:36882
Canis familiaris WDR12 VGNC VGNC:48351
Felis catus WDR12 VGNC VGNC:67015
Others WDR12 NCBI