Zfp36l1 - zinc finger protein 36, C3H type-like 1 Gene

Also Known as Brf1; ERF1; cMG1; Berg36; TIS11b; D530020L18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12192

Summary

Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including 3'-UTR-mediated mRNA destabilization; cellular response to organonitrogen compound; and intracellular signal transduction. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and proepicardium development. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and spinal cord. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Apr 2022]

Zfp36l1 Products (1)

mRNA Protein Name
NM_007564.5 NP_031590.1 mRNA decay activator protein ZFP36L1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
20622884 MGI
enables mRNA 3'-UTR AU-rich region binding IMP
IMP: Inferred from mutant phenotype
27102483 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
24700863 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22701344 MGI
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
20622884 MGI
involved in 3'-UTR-mediated mRNA destabilization IMP
IMP: Inferred from mutant phenotype
24700863 MGI
involved in MAPK cascade IDA
IDA: Inferred from direct assay
24733888 MGI
involved in T cell differentiation in thymus IGI
IGI: Inferred from genetic interaction
20622884 MGI
involved in T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
20622884 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
15226444 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
15226444 MGI
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
19179481 MGI
involved in cellular response to fibroblast growth factor stimulus IDA
IDA: Inferred from direct assay
24733888 MGI
involved in cellular response to peptide hormone stimulus IDA
IDA: Inferred from direct assay
19179481 MGI
involved in cellular response to raffinose IDA
IDA: Inferred from direct assay
24700863 MGI
involved in cellular response to salt stress IDA
IDA: Inferred from direct assay
24700863 MGI
acts upstream of or within chorio-allantoic fusion IMP
IMP: Inferred from mutant phenotype
15226444 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
15226444 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15226444 MGI
involved in mesendoderm development IDA
IDA: Inferred from direct assay
24733888 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15226444 MGI
involved in negative regulation of mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
27102483 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
15226444 MGI
acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
15814898 MGI
involved in p38MAPK cascade IDA
IDA: Inferred from direct assay
17889962 MGI
involved in positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
22701344 MGI
acts upstream of or within proepicardium development IMP
IMP: Inferred from mutant phenotype
15226444 MGI
involved in regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
27102483 MGI
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
20622884 MGI
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
24700863 MGI
involved in regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
17889962 MGI
involved in regulation of stem cell proliferation IDA
IDA: Inferred from direct assay
24733888 MGI
acts upstream of or within regulation of translation IMP
IMP: Inferred from mutant phenotype
17013884 MGI
acts upstream of or within spongiotrophoblast layer development IMP
IMP: Inferred from mutant phenotype
15226444 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
17013884 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11796723 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11796723 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
24700863 MGI
part of ribonucleoprotein complex IMP
IMP: Inferred from mutant phenotype
27102483 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mRNA decay activator protein ZFP36L1

  • TPA-induced sequence 11b

  • ZFP36-like 1

  • butyrate response factor 1

  • zinc finger protein 36, C3H1 type-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16041 ZFP36L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21270 Zfp36l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27788 Zfp36l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zfp36l1 NCBI NCBI:677