Zfp36l2 - zinc finger protein 36, C3H type-like 2 Gene

Also Known as Brf2; ERF2; Tis11d

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12193

Summary

Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including hemopoiesis; negative regulation of cell differentiation; and positive regulation of mRNA catabolic process. Acts upstream of or within hemopoiesis and nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Apr 2022]

Zfp36l2 Products (1)

mRNA Protein Name
NM_001001806.2 NP_001001806.1 mRNA decay activator protein ZFP36L2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
20622884 MGI
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
20622884 MGI
involved in MAPK cascade IDA
IDA: Inferred from direct assay
24733888 MGI
involved in T cell differentiation in thymus IGI
IGI: Inferred from genetic interaction
20622884 MGI
involved in T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
20622884 MGI
involved in cellular response to fibroblast growth factor stimulus IDA
IDA: Inferred from direct assay
24733888 MGI
involved in definitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
19633199 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
19633199 MGI
involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
23748442 MGI
involved in mRNA catabolic process IDA
IDA: Inferred from direct assay
22367205 MGI
involved in negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
22701344 MGI
involved in negative regulation of mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
27102483 MGI
involved in negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
23748442 MGI
acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
15814898 MGI
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
22367205 MGI
involved in regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
27102483 MGI
acts upstream of or within regulation of mRNA stability IDA
IDA: Inferred from direct assay
15467755 MGI
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
20622884 MGI
involved in somatic stem cell division IMP
IMP: Inferred from mutant phenotype
23748442 MGI
involved in somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
23748442 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11796723 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11796723 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mRNA decay activator protein ZFP36L2

  • TPA-induced sequence 11d

  • ZFP36-like 2

  • butyrate response factor 2

  • zinc finger protein 36, C3H1 type-like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16042 ZFP36L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20661 Zfp36l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27172 Zfp36l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zfp36l2 NCBI NCBI:678