ZFP36L2 - ZFP36 ring finger protein like 2 Gene

Also Known as BRF2; ERF2; ERF-2; OOMD13; TIS11D; RNF162C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 678

About ZFP36L2

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,222,402-43,226,606 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues.

Summary

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

ZFP36L2 Products (1)

mRNA Protein Name
NM_006887.5 NP_008818.3 mRNA decay activator protein ZFP36L2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
20506496 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25106868 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IMP
IMP: Inferred from mutant phenotype
25106868 GOA
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
25106868 GOA
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
20166898 GOA
involved in cellular response to fibroblast growth factor stimulus IDA
IDA: Inferred from direct assay
20166898 GOA
involved in cellular response to glucocorticoid stimulus IDA
IDA: Inferred from direct assay
20166898 GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
20166898 GOA
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
20166898 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
20166898 GOA
involved in mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
34611029 GOA
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
25106868 GOA
involved in response to wounding IDA
IDA: Inferred from direct assay
27182009 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP36L2 Protein Structure

Tis11B_N

Tis11B_N: Tis11B like protein, N terminus (1 - 144)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (154 - 180)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (192 - 217)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

mRNA decay activator protein ZFP36L2

  • EGF-response factor 2

ZFP36L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZFP36L2 P47974 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

ZFP36L2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811115 ZFP36L2 Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Achromatopsia 7

  • ACHM7

  • Achromatopsia, Type 7
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16042 ZFP36L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20661 Zfp36l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27172 Zfp36l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZFP36L2 RGD RGD:1308913
Macaca mulatta ZFP36L2 VGNC VGNC:106246
Bos taurus ZFP36L2 VGNC VGNC:54514
Canis familiaris ZFP36L2 VGNC VGNC:48614
Mus musculus ZFP36L2 MGD MGI:107945
Others ZFP36L2 NCBI