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RXFP2 - relaxin family peptide receptor 2 Gene

Also Known as LGR8; GREAT; GPR106; INSL3R; LGR8.1; RXFPR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 122042

About RXFP2

Cytogenetic location: 13q13.1 Genomic coordinates (GRCh38): 13:31,739,526-31,803,389 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 22 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

RXFP2 Products (2)

mRNA	Protein	Name
NM_001166058.2	NP_001159530.1	relaxin receptor 2 isoform 2
NM_130806.5	NP_570718.1	relaxin receptor 2 isoform 1

RXFP2 Protein Structure

Ldl_recept_a

LRR_8

7tm_1

0
200
400
600
754 a.a.

Protein Preferred Names	Protein Names
relaxin receptor 2	G protein coupled receptor affecting testicular descent

Related Diseases

Diseases	Alias
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Infertility
Radiation Cystitis	Irradiation Cystitis
Testicular Torsion	Spermatic Cord Torsion Torsion Of Testis Torsion Of Testicular Cord Torsion Of Testicle Torsion Of Spermatic Cord Torsion Of Spermatic Cord Nos
Hypospadias	Hypospadias Familial Familial Hypospadias
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Prune Belly Syndrome	Eagle-Barrett Syndrome Abdominal Muscle Deficiency Syndrome PBS Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism Egbrs Eagle-Barret Syndrome Urethral Obstruction Sequence Obrinsky Syndrome Triad Syndrome Obrisnksy Syndrome Euos Early Urethral Obstruction Sequence Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism Abdomen Muscle Deficiency Syndrome Abdomen Muscular Deficiency Syndrome Abdominal Muscular Deficiency Syndrome Abdominal Muscle Aplasia Syndrome
Androgen Insensitivity Syndrome	Androgen Resistance Syndrome AIS Testicular Feminization Syndrome Androgen Receptor Deficiency Dhtr Deficiency Dihydrotestosterone Receptor Deficiency Ar Deficiency Testicular Feminization Tfm Androgen Insensitivity Androgen-Insensitivity Syndrome Goldberg-Maxwell Syndrome Complete Androgen Insensitivity Syndrome Cais Feminisation - Testicular Goldberg - Maxwell Syndrome Androgen Insensitivity Syndrome, Complete Morris Syndrome Ary AR Insensitivity Syndrome, Androgen Androgen Insensitivity Nos
Pseudohermaphroditism	Indeterminate Sex And Pseudohermaphroditism
Inguinal Hernia	Hernia Inguinal Hernia, Inguinal Inguinal Hernias Bubonocele Indirect Inguinal Hernia Direct Inguinal Hernia Oblique Inguinal Hernia Scrotal Hernia Ih - [Inguinal Hernia]
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150186	RXFP2 agonist 2		/	Unkown
HY-150185	RXFP2 agonist 1		/	Unkown
HY-RS12358	RXFP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992108	Efadirelaxin alfa	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RXFP2	VGNC	VGNC:64832
Canis familiaris	RXFP2	VGNC	VGNC:54989
Mus musculus	RXFP2	MGD	MGI:2153463
Bos taurus	RXFP2	VGNC	VGNC:52821
Rattus norvegicus	RXFP2	RGD	RGD:1309449
Macaca mulatta	RXFP2	VGNC	VGNC:77039
Others	RXFP2	NCBI