Bsn - bassoon Gene

Mus musculus

Gene ID: 12217 | Gene type: protein coding

About Bsn

Summary

A structural constituent of presynaptic active zone. Involved in presynapse to nucleus signaling pathway; protein localization to synapse; and regulation of synaptic vesicle cycle. Located in several cellular components, including glutamatergic synapse; postsynaptic density; and presynaptic active zone cytoplasmic component. Is active in GABA-ergic synapse and Schaffer collateral - CA1 synapse. Is expressed in nervous system and retina. Used to study epilepsy. Orthologous to human BSN (bassoon presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Bsn Products(1)

mRNA	Protein	Name
NM_007567.2	NP_031593.2	protein bassoon

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17869247	MGI
enables structural constituent of presynaptic active zone	IDA IDA: Inferred from direct assay	21092861	MGI
enables structural constituent of presynaptic active zone	IMP IMP: Inferred from mutant phenotype	21092861	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to synapse	IGI IGI: Inferred from genetic interaction	25652077	MGI
involved in regulation of synaptic vesicle cycle	IDA IDA: Inferred from direct assay	21092860	MGI
involved in regulation of synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	21092860	MGI
involved in synaptic vesicle clustering	IDA IDA: Inferred from direct assay	20332206	MGI
involved in synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	20332206	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	26793095	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	26793095	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26793095	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	26793095	MGI
located in axon	IDA IDA: Inferred from direct assay	23791195	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21940441	MGI
is active in cochlear hair cell ribbon synapse	IDA IDA: Inferred from direct assay	21092861	MGI
is active in cochlear hair cell ribbon synapse	IMP IMP: Inferred from mutant phenotype	21092861	MGI
located in dendrite	IDA IDA: Inferred from direct assay	21940441	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21092860	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21092860	MGI
located in neuron projection terminus	IDA IDA: Inferred from direct assay	12115694	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in presynapse	IDA IDA: Inferred from direct assay	24554721	MGI
located in presynaptic active zone	IDA IDA: Inferred from direct assay	15935055	MGI
located in synapse	IDA IDA: Inferred from direct assay	10900017	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein bassoon

presynaptic cytomatrix protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114591	Spiromesifen	Inhibitor	99.42%	Unkown
HY-114591S	Spiromesifen-d9		/	Unkown
HY-RS01644	BSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bsn	NCBI	NCBI:8927

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