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NAA30 - N-alpha-acetyltransferase 30, NatC catalytic subunit Gene

Also Known as MAK3; Mak3p; NAT12; NAT12P; C14orf35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 122830

About NAA30

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:57,390,586-57,415,906 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 11.4), brain (RPKM 9.1) and 25 other tissues.

Summary

Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation. Located in cytosol and nucleus. Part of NatC complex. Colocalizes with polysome. [provided by Alliance of Genome Resources, Apr 2022]

NAA30 Products (1)

mRNA	Protein	Name
NM_001011713.3	NP_001011713.2	N-alpha-acetyltransferase 30

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptide alpha-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	19398576	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19398576	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein stabilization	IDA IDA: Inferred from direct assay	37891180	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NatC complex	IDA IDA: Inferred from direct assay	19398576	GOA
part of NatC complex	IPI IPI: Inferred from physical interaction	19398576	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19398576	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25732826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA30 Protein Structure

Acetyltransf_1

0
100
200
300
362 a.a.

Protein Preferred Names	Protein Names
N-alpha-acetyltransferase 30	N-acetyltransferase 12 (GCN5-related, putative)

NAA30 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAA30	Q147X3	NAA35	Homo sapiens	Q5VZE5	Cosedimentation	19398576
Intra	NAA30	Q147X3	NAA35	Homo sapiens	Q5VZE5	Anti Tag CoIP	19398576
Intra	NAA30	Q147X3	NAA35	Homo sapiens	Q5VZE5	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurogenic Arthropathy	Neuropathic Arthropathy Arthropathy Associated With Neurological Disorder Charcot'S Arthropathy Charcot'S Joint Arthropathy, Neurogenic Charcot Joint Charcot Or Tabetic Arthropathy Charcot Foot
Villonodular Synovitis	Pigmented Villonodular Synovitis
Ochronosis
Chondrocalcinosis	Pseudogout Calcium Pyrophosphate Deposition Disease Familial Chondrocalcinosis Chondrocalcinosis Nos Cppd - [Calcium Pyrophosphate Deposition Disease] Cpdd - [Calcium Pyrophosphate Deposition Disease] Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site Chondrocalcinosis, Cause Unspecified Chondrocalcinosis Due To Pyrophosphate Crystals Chondrocalcinosis Articularis Calcium Pyrophosphate Arthritis And Periarthritis
Microphthalmia, Syndromic 1	MCOPS1 Lenz Microphthalmia Syndrome Lenz Dysplasia Mcops4 Syndromic Microphthalmia 1 Lenz Microphthalmia Maa Microphthalmia Or Anophthalmos With Associated Anomalies Syndromic Microphthalmia Type 4 Microphthalmia, Syndromic 4 Microphthalmia, Syndromic 4, Formerly Mcops4, Formerly Anop1, Formerly Maa, Formerly Lenz Type Microphthalmia Syndromic Microphthalmia 4 Microphthalmia Lenz Type Microphthalmia Syndromic 1 Syndromic Microphthalmia Type 1 Microphthalmia Syndromic 4 Microphthalmia With Ankyloblepharon And Intellectual Disability Microphthalmia, Lenz Type Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome Microphthalmia, Syndromic, 1 Anop1 Microphthalmia, Syndromic, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08989	NAA30 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NAA30	MGD	MGI:1922259
Bos taurus	NAA30	VGNC	VGNC:54627
Rattus norvegicus	NAA30	RGD	RGD:1559923
Canis familiaris	NAA30	VGNC	VGNC:50549
Macaca mulatta	NAA30	VGNC	VGNC:84405
Felis catus	NAA30	VGNC	VGNC:80907
Others	NAA30	NCBI