SENP8 - SUMO peptidase family member, NEDD8 specific Gene

Also Known as DEN1; NEDP1; PRSC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 123228

About SENP8

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,114,258-72,143,692 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 2.2), thyroid (RPKM 1.6) and 23 other tissues.

Summary

This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

SENP8 Products (5)

mRNA Protein Name
NM_001166340.2 NP_001159812.1 sentrin-specific protease 8
NM_001172109.1 NP_001165580.1 sentrin-specific protease 8
NM_001172110.1 NP_001165581.1 sentrin-specific protease 8
NM_001172111.2 NP_001165582.1 sentrin-specific protease 8
NM_145204.4 NP_660205.3 sentrin-specific protease 8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SENP8 Protein Structure

Peptidase_C48

Peptidase_C48: Ulp1 protease family, C-terminal catalytic domain (26 - 203)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

sentrin-specific protease 8

  • NEDD8 specific-protease cysteine 2

Recombinant SENP8 Proteins

Cat. No. Product Name Accession Purity
HY-P71290 SENP8 Protein, Human (His) Q96LD8 (M1-K212) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
St. Louis Encephalitis

  • Saint Louis Encephalitis

  • Neuroinvasive St. Louis Encephalitis Virus Infection

  • Encephalitis, St. Louis

  • Neuroinvasive Saint Louis Encephalitis Virus Infection

  • St. Louis Encephalitis Virus Infection

  • St. Louis Encephalitis Virus Neuroinvasive Disease

  • St. Louis Viral Disease

  • Type C Lethargic Encephalitis

  • Encephalitis Type C
Kunjin Encephalitis
Kyasanur Forest Disease

  • Kfd

  • Monkey Fever

  • Kfd Virus

  • Kyasanur Hemorrhagic Fever

  • Monkey Disease

  • Monkey Diseases

  • Kfd - [ Kyasanur Forest Disease]

  • Monkey Sickness
Asymptomatic Dengue
Dengue Hemorrhagic Fever

  • Severe Dengue

  • Dengue Haemorrhagic Fever

  • Dhf

  • Severe Dengue Haemorrhagic Fever

  • Severe Dengue Fever

  • Dengue Shock Syndrome
Panophthalmitis
Dengue Disease

  • Dengue Fever

  • Dengue

  • Df

  • Dengue Shock Syndrome

  • Dengue Virus Infection

  • Breakbone Fever

  • Classic Dengue

  • Classical Dengue

  • Dengue Hemorrhagic Fever

  • Hemorrhagic Dengue

  • Philippine Hemorrhagic Fever

  • Singapore Hemorrhagic Fever

  • Thai Hemorrhagic Fever

  • Severe Dengue

  • Dengue Fever Without Warning Signs

  • Dengue Haemorrhagic Fever Grade 1

  • Dengue Haemorrhagic Fever Without Warning Signs

  • Bangkok Haemorrhagic Fever

  • Singapore Haemorrhagic Fever

  • Thailand Haemorrhagic Fever

  • Southeast Asia Haemorrhagic Fever

  • Dhf -[Dengue Haemorrhagic Fever]

  • Dengue Fever With Warning Signs

  • Dengue Haemorrhagic Fever With Warning Signs

  • Dengue Haemorrhagic Fever Grade 2

  • Philippine Haemorrhagic Fever
Dengue Shock Syndrome

  • Dss
Murray Valley Encephalitis

  • Australian Encephalitis

  • Australian X Disease

  • Encephalitis Australia

  • Murray River Encephalitis

  • Australian Arboencephalitis

  • Australian X Disorder

  • Mve - [Murray Valley Encephalitis]
Acalculous Cholecystitis

  • Acute Cholecystitis Without Calculus

  • Acute Acalculous Cholecystitis

  • Cholecystitis Without Calculus
Acute Hemorrhagic Encephalitis
Japanese Encephalitis

  • Japanese B Encephalitis

  • Je

  • Encephalitis Japanese

  • Encephalitis, Japanese

  • Russian Autumnal Encephalitis

  • Je - [Japanese Encephalitis]

  • Japanese Encephalitis Virus Disease

  • Jbe - [Japanese B Encephalitis}

  • B Type Encephalitis
Purulent Endophthalmitis

  • Periocular Infection

  • Acute Endophthalmitis

  • Endophthalmia

  • Eye Infestation Nos

  • Intraocular Infection

  • Eye Infection Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12677 SENP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19481 Senp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25974 Senp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SENP8 MGD MGI:1918849
Macaca mulatta SENP8 VGNC VGNC:77290
Felis catus SENP8 VGNC VGNC:65006
Rattus norvegicus SENP8 RGD RGD:1309955
Canis familiaris SENP8 VGNC VGNC:46008
Others SENP8 NCBI